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A Novel Use of Three-dimensional High-frequency Ultrasonography for Early Pregnancy Characterization in the Mouse
Published on: October 24, 2017
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Tamoxifen and pregnancy: an absolute contraindication?
T N Schuurman1, P O Witteveen2, E van der Wall2
1Department of Gynecologic Oncology, The Netherlands Cancer Institute, Antoni van Leeuwenhoek, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands.
Breast Cancer Research and Treatment
|February 2, 2019
Summary
Tamoxifen use during pregnancy may increase fetal abnormality risk, though evidence is limited. Counseling patients on risks versus benefits is recommended over absolute contraindication for breast cancer treatment.
Area of Science:
- Oncology
- Reproductive Medicine
- Pharmacology
Background:
- Breast cancer is a leading malignancy in women of reproductive age.
- Tamoxifen is an effective adjuvant therapy for hormone-sensitive breast cancer, reducing recurrence risk.
- Tamoxifen is typically contraindicated in pregnancy due to potential fetal risks.
Purpose of the Study:
- To provide a comprehensive overview of existing data on tamoxifen exposure during pregnancy.
- To evaluate the safety profile of tamoxifen use in pregnant breast cancer patients.
Main Methods:
- Literature review conducted using PubMed.
- Searched databases of the Netherlands Pharmacovigilance Centre Lareb.
- Included data from the International Network on Cancer, Infertility, and Pregnancy.
Main Results:
- 238 cases of tamoxifen use during pregnancy were identified.
- 21 of 167 pregnancies with known outcomes showed abnormal fetal development.
- Described malformations were non-specific; most infants were healthy despite tamoxifen exposure.
Conclusions:
- A potential increased risk of fetal abnormalities (12.6%) with tamoxifen in pregnancy exists, but evidence is limited and causality unproven.
- The impact of delaying or stopping tamoxifen on maternal outcomes remains unclear.
- Patients should receive counseling regarding tamoxifen use in pregnancy, rather than a strict contraindication.
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