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Relationship between blood pressure variability and cognitive function in geriatric hypertensive patients with

Erkan Yıldırım1, Emrah Ermis1, Samir Allahverdiyev1

  • 1Department of Cardiology, Biruni University Faculty of Medicine, Istanbul, Turkey.

Aging Clinical and Experimental Research
|February 2, 2019
PubMed

Insights

Increased blood pressure variability is linked to poorer cognitive function in older adults with well-controlled hypertension. This study highlights the importance of monitoring blood pressure fluctuations for cognitive health in this population.

Area of Science:

  • Geriatric Medicine
  • Cardiology
  • Neurology

Background:

  • Hypertension is a significant risk factor for cardiovascular diseases and cognitive impairment.
  • Blood pressure (BP) variability is implicated in cognitive dysfunction, yet data in well-controlled hypertensive geriatric patients are limited.

Purpose of the Study:

  • To investigate the association between blood pressure variability and cognitive function in elderly hypertensive individuals with controlled BP.

Main Methods:

  • Analysis of 435 hypertensive patients undergoing ambulatory BP monitoring.
  • Cognitive function assessed using the standardized mini mental test (sMMT).
  • Blood pressure variability measured by the standard deviation (SD) of systolic BP (SBP).

Main Results:

  • Patients in the highest quartile of SBP variability (≥18.5 mmHg) exhibited significantly lower sMMT scores (p < 0.001).
  • Multivariate logistic regression confirmed that the SD of 24-h SBP was significantly associated with sMMT scores (p = 0.007).

Conclusions:

  • Despite some conflicting research, this study demonstrates a link between elevated 24-hour blood pressure variability and cognitive function in geriatric patients with well-controlled hypertension.
  • Increased blood pressure variability correlates with diminished cognitive performance in this demographic.
Abstract

Keywords:
Ambulatory blood pressure monitoringBlood pressure variabilityCognitive functionHypertensionStandardized mini-mental test

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