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Trabecular bone score in active or former smokers with and without COPD.
Jessica González1, Macarena Rodríguez-Fraile2, Pilar Rivera1
1Pulmonary Department, Clínica Universidad de Navarra, Pamplona, Spain.
Plos One
|February 2, 2019
Summary
Trabecular bone score (TBS) is often affected in smokers, particularly those with Chronic Obstructive Pulmonary Disease (COPD). Body mass index, age, and lung function predict TBS, offering insights for osteoporosis risk assessment in smokers.
Area of Science:
- Bone health and osteoporosis research
- Pulmonary medicine and respiratory health
- Radiology and medical imaging
Background:
- Smoking is a known risk factor for osteoporosis.
- Trabecular bone score (TBS) assesses bone microarchitecture.
- TBS determinants in smokers are not well-established.
Purpose of the Study:
- To evaluate TBS in active and former smokers with and without COPD.
- To identify predictors of TBS in this population.
Main Methods:
- Recruited active/former smokers from a pulmonary clinic.
- Collected clinical data, bone turnover markers, lung function, and CT scans.
- Measured TBS and used logistic regression to find predictive factors.
Main Results:
- 145 patients (97 with COPD) were analyzed.
- COPD patients had significantly lower TBS (1.323 vs. 1.48).
- Higher BMI, younger age, fewer exacerbations, and better FEV1% predicted higher TBS.
Conclusions:
- A significant number of smokers, with or without COPD, exhibit altered TBS.
- BMI, age, exacerbations, and airway obstruction predict TBS in smokers.
- These findings aid in assessing osteoporosis risk in smokers.
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