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|February 2, 2019
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Synthesizing chitosan-poly(methacrylic acid‑co‑N‑isopropylacrylamide) hydrogels at different reaction times impacts their degradation and rifampicin release. Reaction time offers a method to control hydrogel behavior and drug release profiles.

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Area of Science:

  • Biomaterials Science
  • Polymer Chemistry
  • Drug Delivery Systems

Background:

  • Chitosan-poly(methacrylic acid‑co‑N‑isopropylacrylamide) [chitosan‑p(MAA‑co‑NIPAM)] hydrogels exhibit pH and temperature-sensitive behaviors.
  • Previous research indicated synthesis reaction time influences hydrogel properties.

Purpose of the Study:

  • To investigate the effect of varying synthesis reaction times on chitosan‑p(MAA‑co‑NIPAM) hydrogel degradation.
  • To evaluate rifampicin (Rif) loading efficiency and release profiles under acidic and basic conditions.
  • To determine if reaction time can be utilized to modulate hydrogel characteristics and drug release.

Main Methods:

  • Synthesis of chitosan‑p(MAA‑co‑NIPAM) hydrogels with varied reaction times.
  • Assessment of hydrogel degradation rates in acidic and basic environments over two weeks.
  • Measurement of rifampicin loading efficiency.
  • Analysis of rifampicin release kinetics under different pH conditions.

Main Results:

  • Hydrogels exhibited a significantly faster degradation rate in acidic conditions (approx. 50% weight loss) compared to basic conditions (approx. 20% weight loss) within two weeks.
  • Rifampicin loading efficiency was consistently below 50%.
  • Drug release was influenced by hydrogel properties established post-polymerization, rather than solely by synthesis reaction time.

Conclusions:

  • Hydrogel degradation is pH-dependent, proceeding faster in acidic environments.
  • Synthesis reaction time is a critical parameter for controlling the degradation behavior and modifying the drug release profile of chitosan‑p(MAA‑co‑NIPAM) hydrogels.
  • The findings suggest that tailoring synthesis conditions can optimize hydrogel performance for specific drug delivery applications.