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[Bacterial endocarditis: its current course and diagnosis].

A A Demin, V P Drobysheva

    Terapevticheskii Arkhiv
    |January 1, 1988
    PubMed
    Summary

    New diagnostic tests improve bacterial endocarditis (BE) detection and treatment. Positive NBT-tests and antibodies to teichoic acids offer faster, more accurate identification of Staphylococcus aureus, enabling earlier therapy and better prognosis.

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    [Affection of cardiovascular system in antiphospholipid syndrome with non-bacterial thrombotic endocarditis].

    Terapevticheskii arkhiv·2008

    Area of Science:

    • Infectious Diseases
    • Immunology
    • Clinical Microbiology

    Context:

    • Bacterial endocarditis (BE) etiology is shifting towards more virulent pathogens.
    • Traditional diagnostic methods like hemoculture can be slow and less accurate for early detection.
    • Understanding evolving BE pathogens and host responses is crucial for effective management.

    Purpose:

    • To evaluate novel diagnostic markers for bacterial endocarditis.
    • To compare the efficacy of NBT-tests and antibody detection for identifying etiological agents.
    • To assess the utility of autoantibodies in characterizing disease course and prognosis.

    Summary:

    • A positive Nitroblue tetrazolium (NBT) test provides rapid systemic bacterial infection detection, indicating neutrophil phagocytic activity in active BE.
    • High activity of antibodies to teichoic acids accurately identifies Staphylococcus aureus earlier than hemoculture, facilitating timely etiotropic chemotherapy.
    • Enzyme immunoassay for antibodies to native and denatured DNA reveals autoimmune processes, aiding in characterizing BE course and prognosis.
    • Monitoring antibodies to teichoic acids over time can assess therapy effectiveness, as the test becomes negative during inactive disease stages.

    Impact:

    • Earlier and more accurate diagnosis of bacterial endocarditis.
    • Improved selection and timing of antibacterial and etiotropic therapies.
    • Enhanced ability to monitor treatment efficacy and predict disease outcomes.
    • Potential to reduce mortality and morbidity associated with virulent BE pathogens.

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