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Anticipation via canards in excitable systems.

Elif Köksal Ersöz1, Mathieu Desroches1, Claudio R Mirasso2

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Neurons can predict incoming signals using a novel mechanism involving canards. This research explains anticipation in excitable systems and proposes experimental validation for neuroscientists.

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Area of Science:

  • Computational Neuroscience
  • Theoretical Neuroscience
  • Dynamical Systems

Background:

  • Neuronal anticipation of incoming signals is a critical function, yet its underlying physiological mechanisms remain poorly understood.
  • Existing models often lack a comprehensive explanation for how receiver neurons predict sender dynamics in unidirectionally coupled systems.

Purpose of the Study:

  • To propose a novel theoretical framework explaining neuronal anticipation in excitable systems.
  • To elucidate the role of a mathematical object, known as a canard, in mediating predictive capabilities of receiver neurons.
  • To provide a numerical method for analyzing transient canard effects.

Main Methods:

  • Development of a theoretical viewpoint centered on 'canards' to explain anticipation.
  • Numerical simulations to quantify the transient effects of canards.
  • Application of the framework to established models: van der Pol, FitzHugh-Nagumo, and a Hodgkin-Huxley reduction.

Main Results:

  • Demonstrated that canards act as messengers enabling sender prediction in multi-scale excitable systems.
  • Validated the canard-mediated anticipation mechanism across diverse models, including radio-wave circuits and biophysical neuronal models.
  • Proposed a concrete experimental paradigm for neuroscientists to test these predictions.

Conclusions:

  • Canards offer a unifying theoretical explanation for anticipation in excitable systems.
  • The proposed framework provides a foundation for understanding predictive coding in neural networks.
  • Future research can extend this approach to broader classes of excitable systems and explore further implications for neural computation.