Related Experiment Video
Updated: Jan 30, 2026
05:53
Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry
Published on: June 21, 2018
10.7K
Outcomes and practice patterns with hemodiafiltration in Shanghai: a longitudinal cohort study
Weiming Zhang1, Changlin Mei2, Nan Chen3
1Department of Nephrology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200127, China.
BMC Nephrology
|February 3, 2019
Summary
Hemodiafiltration (HDF) shows clinical benefit in China, potentially improving patient outcomes by removing more uremic toxins. This study analyzed HDF practice patterns and mortality risk in Shanghai, finding a significant benefit in younger patients.
Area of Science:
- Nephrology
- Epidemiology
- Clinical Medicine
Background:
- Growing global interest in hemodiafiltration (HDF) for enhanced uremic toxin removal.
- Lack of epidemiological data on HDF practices and outcomes in China.
- Focus on HDF in Shanghai to understand its utilization and impact.
Purpose of the Study:
- To analyze hemodiafiltration (HDF) practice patterns in Shanghai.
- To assess the association between HDF and patient mortality risk.
- To provide the first epidemiological analysis of HDF in China.
Main Methods:
- Observational, prospectively collected, retrospective analysis of 9351 patients in Shanghai (2007-2014).
- Primary exposure: hemodialysis (HD) vs. hemodiafiltration (HDF).
- Cox and Fine-Gray regression models used to analyze patient mortality, adjusting for covariates.
Main Results:
- HDF utilization increased from 7% to 42% between 2007 and 2014.
- Overall adjusted hazard ratio for HDF vs. HD was 0.85 (not statistically significant).
- Significant mortality reduction observed with HDF in patients aged 40-60 years (HR 0.65).
Conclusions:
- Evidence suggests clinical benefit of HDF in China, with potential for improved patient outcomes.
- Greater removal of middle and larger molecular weight uremic solutes by HDF may contribute to benefits.
- Further research warranted despite study limitations, including data availability and covariate scope.
Related Concept Videos
01:26Longitudinal Studies
521
Longitudinal studies are also widely used in other medical and social science fields. For instance, in cardiovascular research, they can monitor patients' health over decades to identify risk factors for heart disease, such as high cholesterol or smoking, and evaluate the long-term effectiveness of preventive measures. Similarly, in mental health studies, researchers might follow individuals from adolescence into adulthood to understand the development and progression of conditions like...
521
02:20Longitudinal Research
13.3K
Sometimes we want to see how people change over time, as in studies of human development and lifespan. When we test the same group of individuals repeatedly over an extended period of time, we are conducting longitudinal research. Longitudinal research is a research design in which data-gathering is administered repeatedly over an extended period of time. For example, we may survey a group of individuals about their dietary habits at age 20, retest them a decade later at age 30, and then again...
13.3K
02:24Predicting Reaction Outcomes
10.8K
Kinetics describes the rate and path by which a reaction occurs. In contrast, thermodynamics deals with state functions and describes the properties, behavior, and components of a system. It is not concerned with the path taken by the process and cannot address the rate at which a reaction occurs. Although it does provide information about what can happen during a reaction process, it does not describe the detailed steps of what appears on an atomic or a molecular level. On the other hand,...
10.8K
01:13Outcomes of Glycolysis
107.1K
Nearly all the energy used by cells comes from the bonds that make up complex organic compounds. These organic compounds are broken down into simpler molecules, such as glucose. As a result, cells extract energy from glucose over many chemical reactions—a process called cellular respiration.
Cellular respiration can occur aerobically (with oxygen) or anaerobically (without oxygen). In the presence of oxygen, cellular respiration starts with glycolysis and continues with pyruvate...
Cellular respiration can occur aerobically (with oxygen) or anaerobically (without oxygen). In the presence of oxygen, cellular respiration starts with glycolysis and continues with pyruvate...
107.1K
01:06Fixed Action Patterns
17.6K
A fixed action pattern (FAP) is a specific, hard-wired sequence of behaviors that occurs in response to an external stimulus, called a sign stimulus. The behavior is “fixed” because it is essentially unchangeable—proceeding similarly across individuals of a species every time it occurs.
17.6K
01:11Guidelines for Writing Outcome
3.8K
When developing expected outcomes for a patient care plan, the nurse should adhere to the following recommendations:
Patient outcomes reflect the patient's response to the goal rather than what the nurse aims to achieve. Terminology should be observable and measurable to avoid the reader's interpretation. The desired outcome should be realistic and achievable in the designated care timeframe. Expected outcomes should align with adjunctive therapies. The outcome should enhance care...
Patient outcomes reflect the patient's response to the goal rather than what the nurse aims to achieve. Terminology should be observable and measurable to avoid the reader's interpretation. The desired outcome should be realistic and achievable in the designated care timeframe. Expected outcomes should align with adjunctive therapies. The outcome should enhance care...
3.8K