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Updated: Jan 30, 2026

Protocol for Production of a Genetic Cross of the Rodent Malaria Parasites
Published on: January 3, 2011
para-Aminobenzoate Synthesis versus Salvage in Malaria Parasites
Michael W Mather1, Hangjun Ke1
1Center for Molecular Parasitology, Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, PA 19129, USA.
Abstract:
Enzymes of the folate de novo synthesis pathway in malaria parasites are proven antimalarial drug targets. A key precursor for folate synthesis is para-aminobenzoate (pABA). In a recent study [1] (Cell Rep. 2019;26:356-363 e4), the contributions of pABA synthesis versus salvage were re-evaluated in a rodent malaria model with knockout parasites grown in mice fed with various diets. The results imply that malaria parasites can either synthesize or salvage pABA to meet the demand for folates.
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