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An Imidazo[1,5-α]Pyridine-Based Fluorometric Chemodosimeter for the Highly Selective Detection of Hypochlorite in
Suh Mi Hwang1, Dongju Yun1, Cheal Kim2
1Department of Fine Chemistry, Seoul National University of Science and Technology, Seoul, 129-743, South Korea.
Abstract:
A new fluorometric chemodosimeter 2-amino-3-(((E)-3-(1-phenylimidazo[1,5-α]pyridin-3-yl)benzylidene)amino)maleonitrile (BPI-MAL) has been designed and synthesized for sensing hypochlorite. BPI-MAL showed a selective turn-on fluorescence for ClO- through hypochlorite-promoted de-diaminomaleonitrile reaction. It also could detect ClO- in the presence of various competitive anions including reactive oxygen species. Interestingly, sensor BPI-MAL was successfully applied as a fluorescent test kit for ClO- determination. The sensing property and mechanism of BPI-MAL toward ClO- were studied by fluorescence and UV-vis spectroscopy, NMR titration and DFT calculations.
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