Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Introduction to Innate and Adaptive Immunity01:21

Introduction to Innate and Adaptive Immunity

9.4K
The human immune system is a complex defense mechanism that protects the body from harmful pathogens and foreign substances. It comprises two crucial components: innate and adaptive immunity.
Innate immunity is the body's natural, nonspecific defense system that acts quickly to protect against pathogens. It incorporates physical barriers like skin and mucous membranes and cellular elements such as phagocytes and natural killer cells. This part of our immune system provides an immediate,...
9.4K
Special Features of Adaptive Immunity01:20

Special Features of Adaptive Immunity

3.3K
The adaptive immune system, a crucial component of the overall immune response, offers a highly specialized defense against pathogens. It involves specific cell types and features, enabling it to combat infections effectively and efficiently.
The primary cell types involved in adaptive immunity are T cells and B cells. Each type has a unique role in defending the body against pathogens. T cells are responsible for cell-mediated immunity. They identify and eliminate infected cells directly,...
3.3K
Cells of the Adaptive Immune Response01:23

Cells of the Adaptive Immune Response

8.8K
The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
8.8K
Antigens Involved in Adaptive Immunity01:26

Antigens Involved in Adaptive Immunity

1.4K
An antigen is any substance the immune system identifies as foreign and potentially harmful to the body, prompting an immune response. Antigens have two functional properties: immunogenicity and reactivity. Immunogenicity is the ability of an antigen to stimulate a specific immune response. At the same time, reactivity describes the antigen's ability to react with the cells and antibodies produced in response to it.
Complete Antigens
Complete antigens possess both immunogenicity and...
1.4K
What is the Immune System?01:38

What is the Immune System?

127.7K
Overview
127.7K
Anatomy of the Intestines01:23

Anatomy of the Intestines

87.3K
Although digestion of proteins, carbohydrates, and lipids may begin in the stomach, it is completed in the intestine. The absorption of nutrients, water, and electrolytes from food and drink also occurs in the intestine. The intestines can be divided into two structurally distinct organs—the small and large intestines.
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
87.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Goblet cell-associated antigen passages in health and disease.

Current opinion in gastroenterology·2026
Same author

Gut microbiota translocation and dissemination in health: can it be beneficial and purposeful?

Gut microbes·2026
Same author

Kinetics of local C3 production orchestrates neutrophil recruitment in lung injury.

bioRxiv : the preprint server for biology·2026
Same author

Mucosally sourced complement factor B modulates the host response to colitis.

bioRxiv : the preprint server for biology·2026
Same author

Impaired complement regulation drives chronic lung allograft dysfunction after lung transplantation.

The Journal of clinical investigation·2025
Same author

Early life infection with <i>Cryptosporidium parvum</i> induces inflammatory responses to dietary antigens.

Gut microbes·2025

Related Experiment Video

Updated: Jan 29, 2026

Isolating Lymphocytes from the Mouse Small Intestinal Immune System
11:28

Isolating Lymphocytes from the Mouse Small Intestinal Immune System

Published on: February 28, 2018

56.7K

Intestinal Macromolecular Transport Supporting Adaptive Immunity.

Devesha H Kulkarni1, Rodney D Newberry1

  • 1Department of Internal Medicine, Washington University School of Medicine, St. Louis, Missouri.

Cellular and Molecular Gastroenterology and Hepatology
|February 3, 2019
PubMed
Summary

The gastrointestinal tract epithelium absorbs nutrients and maintains a barrier. It also transports macromolecules to induce adaptive immunity, offering insights into inflammatory diseases.

Keywords:
Antigen TransportGoblet CellsMucosal Tolerance

More Related Videos

Canine Intestinal Organoids in a Dual-Chamber Permeable Support System
11:11

Canine Intestinal Organoids in a Dual-Chamber Permeable Support System

Published on: March 2, 2022

4.3K
Using Caco-2 Cells to Study Lipid Transport by the Intestine
07:00

Using Caco-2 Cells to Study Lipid Transport by the Intestine

Published on: August 20, 2015

19.7K

Related Experiment Videos

Last Updated: Jan 29, 2026

Isolating Lymphocytes from the Mouse Small Intestinal Immune System
11:28

Isolating Lymphocytes from the Mouse Small Intestinal Immune System

Published on: February 28, 2018

56.7K
Canine Intestinal Organoids in a Dual-Chamber Permeable Support System
11:11

Canine Intestinal Organoids in a Dual-Chamber Permeable Support System

Published on: March 2, 2022

4.3K
Using Caco-2 Cells to Study Lipid Transport by the Intestine
07:00

Using Caco-2 Cells to Study Lipid Transport by the Intestine

Published on: August 20, 2015

19.7K

Area of Science:

  • Gastroenterology
  • Immunology
  • Epithelial Biology

Background:

  • The gastrointestinal (GI) tract epithelium balances nutrient absorption, barrier function, and immune system interaction.
  • It processes nutrients, prevents pathogen entry, and delivers luminal substances to initiate adaptive immunity.

Purpose of the Study:

  • To review historical and recent findings on intestinal epithelial macromolecule transport.
  • To explore the regulation of this transport in promoting adaptive immunity.
  • To connect this process to gastrointestinal inflammatory diseases.

Main Methods:

  • Literature review of historical observations and recent research.
  • Analysis of studies on macromolecule transport mechanisms.
  • Examination of regulatory pathways governing immune responses.

Main Results:

  • The intestinal epithelium actively transports macromolecules to the immune system.
  • Specific transport mechanisms are crucial for nutrient uptake and immune signaling.
  • Regulation of macromolecule delivery influences tolerogenic or protective immunity.

Conclusions:

  • Understanding macromolecule transport is key to comprehending GI immune responses.
  • Dysregulation of this transport may contribute to inflammatory GI diseases.
  • Insights may lead to novel therapeutic strategies for GI disorders.