Related Experiment Video
Updated: Jan 29, 2026
09:20
In situ Subcellular Fractionation of Adherent and Non-adherent Mammalian Cells
Published on: July 23, 2010
16.3K
Methods for Measuring Multiple Medication Adherence: A Systematic Review-Report of the ISPOR Medication Adherence and
Priti P Pednekar1, Tamás Ágh2, Maria Malmenäs3
1Mayes College of Healthcare Business and Policy, University of the Sciences, Philadelphia, PA, USA.
Summary
Measuring multiple medication adherence (MMA) lacks standardized methods, with studies using varied approaches like proportion of days covered, medication possession ratio, and self-reported questionnaires. Further research is needed to develop robust measures for complex medication regimens.
Area of Science:
- Pharmacology
- Health Services Research
- Evidence-Based Practice
Background:
- Limited literature exists on measuring adherence to multiple medications compared to single-drug regimens.
- Polypharmacy is increasingly prevalent, necessitating effective adherence measurement tools.
Purpose of the Study:
- To identify and characterize the various methods used to measure multiple medication adherence (MMA) in published literature.
Main Methods:
- A systematic literature review was conducted using multiple databases (PubMed, PsycINFO, etc.) from 1973 to 2015.
- Studies were screened in two steps: abstract review followed by full-text analysis.
- Data on study characteristics and MMA measurement methods were extracted and summarized.
Main Results:
- 147 studies from 32 countries across 13 disease states were included.
- Common MMA methods included self-reported questionnaires (72 studies), proportion of days covered (26 studies), and medication possession ratio (23 studies).
- Approximately 50% of studies employed multiple MMA measurement methods, often with variations in calculation.
Conclusions:
- No standardized method for measuring multiple medication adherence (MMA) was identified.
- Development of robust MMA measures is crucial given the rise in polypharmacy.
- Future research should focus on the validity, reliability, and clinical impact of MMA measures.
Related Concept Videos
01:23Inhaled Medications
792
Inhaled medications are crucial for managing chronic obstructive pulmonary disease (COPD) and asthma. They are essential for effective treatment and control, ensuring optimal respiratory health and well-being. Inhaled medication delivers drugs directly to the lungs, providing a rapid onset of action and reducing systemic side effects compared to oral or injectable medications. Three primary types of inhalation devices are used to administer these medications: nebulizers, metered-dose inhalers...
792
01:18Endocarditis III: Medical Management
254
Infective endocarditis management involves a multifaceted approach encompassing infection prevention, lifestyle modifications, pharmacological therapy, and surgical management.Infection Prevention:Hand Hygiene: Thorough handwashing is crucial to prevent the spread of infection. Hand hygiene should be performed regularly, especially before and after using the restroom.Oral Hygiene: Good oral hygiene is essential. It includes brushing teeth immediately after waking up and before bed, flossing...
254
01:14Myocarditis III: Medical Management
216
Myocarditis: Comprehensive Medical ManagementMyocarditis, the heart muscle inflammation, requires a comprehensive medical management strategy that addresses the underlying cause, provides supportive care, manages symptoms, and reduces cardiac workload.Infections and Autoimmune CausesAdminister appropriate antimicrobial therapy when an infectious agent causes myocarditis. For instance, penicillin treats infections caused by Group A Streptococcus. In cases where autoimmune processes are...
216
01:17Pericarditis III: Medical Management
349
The primary objectives of managing pericarditis are to determine the underlying cause, provide effective therapy for treatment and symptom relief, and promptly detect signs and symptoms of cardiac tamponade. The following outlines the essential aspects of medical management for pericarditis:ObjectivesDetermine the Cause: Identifying the underlying cause of pericarditis is crucial for targeted treatment. Causes include viral infections, autoimmune diseases, post-cardiac injury syndrome, and...
349
01:30Heart Failure V: Medical Management
305
Medical Management of Acute Decompensated Heart Failure (ADHF)The primary goals of therapy for patients hospitalized with acute decompensated heart failure (ADHF) include:Relieving symptomsOptimizing volume statusSupporting oxygenation and ventilationMaintaining cardiac output (CO) and end-organ perfusionIdentifying and addressing the cause of ADHFPreventing complicationsProviding patient education on factors precipitating HF exacerbationPlanning for dischargeOngoing monitoring and assessment...
305
01:26Mitral Stenosis III: Medical Management
288
Mitral stenosis, a condition marked by the narrowing of the mitral valve, necessitates an integrated approach for effective management. This approach includes preventative measures, medical therapy, and surgical interventions to reduce symptoms and prevent complications.PreventionPrevention of mitral stenosis primarily focuses on reducing the incidence of bacterial infections, particularly streptococcal infections, which can lead to rheumatic fever and subsequent valvular damage. Timely...
288