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Related Experiment Videos

Fifteen years' experience with the Multiload IUD.

W A Van Os1, D A Edelman

  • 1Elisabeth Gasthuis, Department of Obstetrics and Gynaecology, Haarlem, The Netherlands.

Advances in Contraception : the Official Journal of the Society for the Advancement of Contraception
|September 1, 1988
PubMed
Summary

The Multiload intrauterine device (IUD) is a safe and effective contraceptive. Larger copper surface area IUDs, like the Multiload 375, may reduce ectopic pregnancy risks, with benefits outweighing potential complications.

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Area of Science:

  • Reproductive Health
  • Medical Devices
  • Contraception

Background:

  • The Multiload intrauterine device (IUD) with a 250 mm2 copper surface area (MLCu250) has been widely used since 1972.
  • Modifications include the MLCu375 with a larger copper surface area (375 mm2) and thicker copper wire.

Purpose of the Study:

  • To evaluate the performance and safety of the Multiload IUD (MLCu250 and MLCu375).
  • To compare Multiload IUDs with other intrauterine devices.

Main Methods:

  • Extensive evaluation through noncomparative and comparative clinical trials.
  • Analysis of pooled data from over 26,000 MLCu250 insertions.
  • Review of comparative studies assessing pelvic inflammatory disease and ectopic pregnancy rates.

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Main Results:

  • MLCu250 demonstrated better performance than Cu-7 and TCu-200.
  • MLCu375 performed comparably to TCu380 and better than Fincoid or Nova T.
  • Three-year cumulative event rates for MLCu250: 2.0% pregnancy, 3.1% expulsion, 7.1% removal for pain/bleeding.
  • All current IUDs show similar pelvic inflammatory disease rates.
  • Larger copper surface area IUDs (MLCu375) are linked to lower ectopic pregnancy rates.
  • Multiload IUD use does not impair future fertility or affect pregnancy outcomes.

Conclusions:

  • The Multiload IUD, particularly the MLCu375, is an effective contraceptive option.
  • Benefits of IUD usage significantly outweigh the risks of complications.
  • Larger copper surface area IUDs may offer an advantage in reducing ectopic pregnancy risk.