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Area of Science:

  • Neurology
  • Pharmacology

Background:

  • Postconcussion syndrome (PCS) presents diverse symptoms, including headaches, cognitive issues, and mood disorders after traumatic brain injury (TBI).
  • Limited medication data exists for persistent post-traumatic headaches (PTH).

Purpose of the Study:

  • To evaluate amantadine's efficacy for postconcussion syndrome symptoms, particularly persistent headaches.
  • To assess amantadine's effectiveness in treating post-traumatic headaches (PTH) after traumatic brain injury (TBI).

Main Methods:

  • Retrospective review of medical records from Mayo Clinic outpatient clinics.
  • Analysis of 33 patients diagnosed with PCS and prescribed amantadine (100 mg twice daily for 2 months).

Main Results:

  • 80% of patients completing a full amantadine trial showed improvement in post-traumatic headaches (PTH).
  • Headache improvement occurred even when amantadine was prescribed years post-TBI.
  • Significant improvement was not observed in other PCS symptoms like memory or dizziness.

Conclusions:

  • Amantadine may be a viable treatment option for persistent headaches following traumatic brain injury (TBI).
  • Further research is warranted to confirm amantadine's role in managing post-traumatic headaches (PTH).