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Updated: Jan 29, 2026

Functional Imaging of Brown Fat in Mice with 18F-FDG micro-PET/CT
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Functional Imaging of Brown Fat in Mice with 18F-FDG micro-PET/CT

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Persistent FDG/PET CT uptake in idiopathic retroperitoneal fibrosis helps identifying patients at a higher risk for

Gabriel Morin1, Arthur Mageau1, Khadija Benali2

  • 1Département de Médecine Interne, Hôpital Bichat, PRES Sorbonne Paris Cité, Assistance Publique Hôpitaux de Paris, Université Paris Diderot, Paris, France.

European Journal of Internal Medicine
|February 4, 2019
PubMed
Abstract

Insights

Persistent FDG uptake in idiopathic retroperitoneal fibrosis (IRF) indicates a higher risk of relapse. FDG-PET CT can help predict outcomes and guide treatment for IRF patients.

Area of Science:

  • Nuclear Medicine
  • Radiology
  • Oncology

Background:

  • Idiopathic retroperitoneal fibrosis (IRF) is a rare condition.
  • Assessing the prognostic value of FDG uptake in IRF is crucial for patient management.

Purpose of the Study:

  • To evaluate the prognostic significance of persistent fluorodeoxyglucose (FDG) uptake in idiopathic retroperitoneal fibrosis (IRF) using FDG-PET CT.
  • To determine if FDG uptake can predict relapse rates in IRF patients.

Main Methods:

  • A retrospective cohort study included 23 patients diagnosed with IRF between 2009 and 2017.
  • FDG-PET CT scans were performed at diagnosis and during follow-up to measure maximal standardized uptake value (SUVmax) of retroperitoneal fibrosis.
  • Relapse rate was the primary outcome, with multivariate analysis used to identify predictors of relapse.

Main Results:

  • All patients showed high FDG uptake at diagnosis (SUVmax 6.5).
  • Persistent FDG uptake was observed in 69.6% at the first evaluation and 52.2% at the second.
  • Persistent FDG uptake at the second evaluation was significantly associated with IRF relapse (p=0.046).

Conclusions:

  • Persistent FDG uptake in IRF during follow-up is linked to clinical outcomes.
  • FDG-PET CT imaging can aid in risk stratification and targeted therapy for IRF.
Keywords:
FDG/PET CTIdiopathic retroperitoneal fibrosisRelapse

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