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Gait quantification in multiple sclerosis: A single-centre experience of systematic evaluation.

Pierre Decavel1, Yoshimasa Sagawa1

  • 1Laboratoire d'exploration fonctionnelle clinique du mouvement, university hospital of Besançon, 25000 Besançon, France; Integrative and clinical neurosciences EA481, Bourgogne Franche-Comte university, 25000 Besançon, France.

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Gait evaluations in multiple sclerosis (MS) require reproducible measures. This study proposes a minimum set of gait assessments for clinical practice and research to improve outcomes for persons with MS.

Keywords:
LocomotionMeasurement setMultiple sclerosisReproducibilitySystematic evaluation

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Area of Science:

  • Neurology
  • Rehabilitation Medicine
  • Biomedical Engineering

Background:

  • Gait disorders are a significant disabling factor for persons with multiple sclerosis (PMS).
  • Current gait evaluation methods vary in relevance and reproducibility for PMS.
  • Short-distance gait evaluations are considered for clinical research endpoints but may lack clinical relevance and metrological rigor.

Purpose of the Study:

  • To evaluate the advantages and limitations of various gait tests in persons with multiple sclerosis (PMS).
  • To propose a standardized minimum set of gait measurements for clinical practice and research in MS.
  • To enhance the reliability and clinical utility of gait assessments in MS.

Main Methods:

  • Utilized a range of walk tests: timed 25-foot walk (comfortable, fast, dual-task), Timed Up and Go, and 6-minute walk test.
  • Incorporated neuromotor analysis of lower limbs.
  • Synthesized 4 years of clinical experience to inform recommendations.

Main Results:

  • Different gait parameters and walk tests present varying degrees of reproducibility and clinical relevance for PMS.
  • Short-distance evaluations may not always be optimal or sufficiently reproducible for MS research.
  • A comprehensive approach combining multiple walk tests and neuromotor analysis is beneficial.

Conclusions:

  • Standardized and reproducible gait evaluations are crucial for assessing therapeutic strategies in PMS.
  • A proposed minimum set of gait measurements can improve consistency in clinical practice and research.
  • Optimized gait assessments will better serve the needs of persons with MS.