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Tick-Pathogen Interactions: The Metabolic Perspective
Alejandro Cabezas-Cruz1, Pedro Espinosa2, Pilar Alberdi2
1UMR BIPAR, INRA, Ecole Nationale Vétérinaire d'Alfort, ANSES, Université Paris-Est, Maisons-Alfort, France.
Trends in Parasitology
|February 4, 2019
Summary
Tick metabolism shifts during infection, reprogramming pathways to aid pathogen survival and transmission. This review focuses on how Anaplasma phagocytophilum alters tick metabolic processes.
Area of Science:
- Molecular biology
- Tick-borne disease research
- Host-pathogen interactions
Background:
- The tick genome (2016) aids study of tick-pathogen interactions.
- Tick metabolism is crucial but poorly understood in host-pathogen contexts.
- Tick-borne pathogens significantly impact host metabolism.
Purpose of the Study:
- To review the current understanding of tick metabolism modulation by tick-borne pathogens.
- To highlight the role of Anaplasma phagocytophilum in altering tick metabolism.
Main Methods:
- Systems biology approaches using omics datasets.
- Analysis of transcriptional reprogramming in response to infection.
- Literature review of existing studies.
Main Results:
- Pathogen infection induces significant transcriptional changes in tick metabolic pathways.
- Altered tick metabolism facilitates pathogen infection, multiplication, and transmission.
- Tick cellular response to pathogens involves tolerance mechanisms.
Conclusions:
- Tick metabolism is actively modulated by tick-borne pathogens.
- Understanding these metabolic interactions is key to controlling disease transmission.
- Anaplasma phagocytophilum serves as a model for studying these complex interactions.
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