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A new scheme for rational design and synthesis of polyoxovanadate hybrids with high antitumor activities
Xiaokang Hu1, Huan Wang1, Bo Huang1
1Institute of POM-based Materials, Hubei Provincial Key Laboratory of Green Materials for Light Industry, National "111" Center for Cellular Regulation and Molecular Pharmaceutics, Sino-German Biomedical Center, Hubei University of Technology, Wuhan 430068, China.
Abstract:
A new strategy to construct polyoxovanadate hybrids incorporating amino acid esters in mild conditions was presented in this paper. These new hybrids were not only structurally determined by Single Crystal X-Ray diffraction, but also exhibited higher antitumor activities against laryngeal carcinoma, rhabdomyoma, and breast adenocarcinoma tumor cells compared with the traditional commercial medicine 5-fluorouracil. These results would provide a promising lead scaffold for further design and synthesis of potential anticancer agents.
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