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Updated: Jan 29, 2026

Solid Lipid Nanoparticles SLNs for Intracellular Targeting Applications
Published on: November 17, 2015
Poly (N-isopropylacrylamide) based hydrogels as novel precipitation and stabilization media for solid lipid
Sushilkumar A Jadhav1, Valentina Brunella2, Simona Sapino3
1Department of Chemistry and NIS Research Centre, University of Torino, Via P. Giuria 7, 10125 Torino, Italy; School of Nanoscience and Technology, Shivaji University Kolhapur, 416004 Kolhapur, Maharashtra, India.
Abstract:
In this work, poly(N-isopropylacrylamide) (PNIPAM) based chemically cross-linked hydrogels are used as novel precipitation and stabilization media for solid lipid nanoparticles (SLNs) for the first time. The hydrogels and the hybrid thermoresponsive composite hydrogels with SLNs were characterized by SEM, DSC, DLS and rheometric analysis. The results showed that the SLNs obtained directly in the gel matrix by the newly devised method were well-dispersed and remained stable for one month. A remarkable advantage of this approach is that it yields the thermoresponsive nanocomposite hydrogels in a single step. This approach is a significant advancement in the preparation of hybrid thermoresponsive nanocomposite systems based on smart gels and SLNs for their use in biomedical applications.
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