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Integrin as a Molecular Target for Anti-cancer Approaches in Lung Cancer

Nithikoon Aksorn1, Pithi Chanvorachote2,3

  • 1Department of Clinical Pathology, Faculty of Medicine Vajira Hospital, Navamindradhiraj University, Bangkok, Thailand.

Anticancer Research
|February 4, 2019
PubMed

Insights

Integrins are key cell adhesion molecules involved in cancer progression. Targeting specific integrins shows promise for improving lung cancer therapy and overcoming drug resistance.

Area of Science:

  • Cell Biology
  • Molecular Oncology
  • Cancer Therapeutics

Background:

  • Integrins mediate cell-matrix adhesion and signaling, crucial for cell functions.
  • These functions are implicated in cancer development and progression.
  • Specific integrins (αv, α5, β1, β3, β5) are linked to lung cancer survival and metastasis.

Purpose of the Study:

  • To review the role of integrins in lung cancer.
  • To explore integrins as potential molecular targets for anti-cancer therapies.
  • To understand how integrins contribute to drug resistance and metastasis in lung cancer.

Main Methods:

  • Literature review of studies on integrins in lung cancer.
  • Analysis of data linking integrin expression to cancer cell survival and metastasis.
  • Examination of mechanisms of integrin-mediated chemoresistance and metastatic potential.

Main Results:

  • Integrins play significant roles in lung cancer cell survival and metastasis.
  • Certain integrins enhance the metastatic potential of lung cancer cells.
  • Integrins contribute to lung cancer resistance to chemotherapeutics.

Conclusions:

  • Integrins are viable molecular targets for novel anti-cancer strategies.
  • Targeting integrins may overcome chemoresistance and reduce lung cancer metastasis.
  • Further understanding of integrin mechanisms can guide the development of new anti-cancer drugs.
Keywords:
Integrinanti-cancer drugdrug discoverylung cancerreviewtarget therapy

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