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Updated: Jan 29, 2026

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Curcumin and Cinnamaldehyde as PTP1B Inhibitors With Antidiabetic and Anticancer Potential

Tomasz Kostrzewa1, Paulina Przychodzen1, Magdalena Gorska-Ponikowska1

  • 1Department of Medical Chemistry, Medical University of Gdansk, Gdansk, Poland.

Anticancer Research
|February 4, 2019
PubMed
Abstract

Insights

Curcumin and cinnamaldehyde inhibit protein tyrosine phosphatase 1B (PTP1B) activity and reduce cancer cell viability. Curcumin demonstrated a stronger inhibitory effect, suggesting its potential for treating type 2 diabetes and cancer.

Area of Science:

  • Biochemistry
  • Pharmacology
  • Oncology

Background:

  • Protein tyrosine phosphatase 1B (PTP1B) is a key target for type 2 diabetes and cancer therapies.
  • Curcumin and cinnamaldehyde are natural compounds with reported antidiabetic and anticancer properties.

Purpose of the Study:

  • To compare the effects of curcumin and cinnamaldehyde on PTP1B enzymatic activity.
  • To evaluate their impact on the viability of MCF-7 breast cancer cells.

Main Methods:

  • Enzymatic activity assays were performed.
  • Cell viability assays were conducted using the MCF-7 cell line.

Main Results:

  • Both curcumin and cinnamaldehyde inhibited PTP1B activity.
  • Both compounds reduced the viability of MCF-7 cancer cells.
  • Curcumin exhibited a significantly greater inhibitory effect compared to cinnamaldehyde.

Conclusions:

  • Curcumin shows potential as an therapeutic agent for type 2 diabetes and cancer.
  • Further research into curcumin's mechanism of action is warranted.
Keywords:
PTP1B phosphataseType 2 diabetescancercinnamaldehydecurcuminobesity

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