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Bilateral kidney translocation in sheep.

A N Baird1, S A Brown, L P Jones

  • 1Department of Large Animal Medicine and Surgery, Texas Veterinary Medical Center, Texas A&M University, College Station 77843.

American Journal of Veterinary Research
|December 1, 1988
PubMed
Summary
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Bilateral kidney translocation in sheep showed minimal impact on kidney function and histology, with most biopsy sites healing effectively. This model is suitable for toxicity studies, potentially reducing animal usage.

Area of Science:

  • Veterinary Surgery
  • Nephrology
  • Animal Models

Background:

  • Surgical innovation in animal models is crucial for advancing preclinical research.
  • Assessing the long-term effects of surgical procedures on organ function is essential.
  • Developing reliable animal models can reduce the need for extensive human trials.

Purpose of the Study:

  • To evaluate the feasibility and impact of bilateral kidney translocation in adult sheep.
  • To assess renal function and histological changes following kidney translocation surgery.
  • To determine the suitability of this model for nephrotoxicity and tissue residue studies.

Main Methods:

  • Bilateral kidney translocation surgery was performed on 7 adult sheep.
  • Percutaneous renal biopsy specimens (40 mg each) were collected between 36 and 110 days post-surgery.

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  • Serum urea nitrogen and creatinine levels were monitored, and histological examination was performed post-necropsy.

    • Main Results:

    • Serum urea nitrogen and creatinine remained within normal limits up to postoperative day 66.
    • Histological examination at 113 days post-surgery revealed 75-90% normal kidney tissue.
    • Abnormal areas were attributed to resolving biopsy lesions, indicating successful healing.

    Conclusions:

    • Bilateral kidney translocation is a viable surgical model in sheep with minimal long-term renal impairment.
    • The model demonstrates good recovery from biopsy procedures, supporting its use in preclinical studies.
    • This surgical approach may offer a more ethical and efficient alternative for toxicity and residue studies.