Related Experiment Video For CA 19.9
Updated: Jan 7, 2026

Standardized SDS-PAGE Workflow for Personalized Protein Corona Profiling in Early Cancer Detection
Published on: December 19, 2025
Serum CA 19.9 Levels in Patients With Benign and Malignant Disease: Correlation With the Serum Protein
Simon Gundín-Menéndez1, Victor Molina Santos2, Marina Parra-Robert3
1Laboratory of Biochemistry, Marqués de Valdecilla University Hospital, Santander, Spain.
Aim:
To confirm that the carbohydrate antigen 19.9 (CA 19.9) protein can be evaluated by determining changes in the β2 zone in protein electrophoresis.
Materials And Methods:
A total of 75 patients (64 with cancer, 11 with benign diseases) with abnormal serum CA 19.9 level were included.
Results:
Patients with cancer had significantly higher serum CA 19.9 concentrations than those with benign diseases (p<0.001). Similar CA 19.9 levels were observed in patients with normal (median 1129 U/ml), weakly positive (median 699 U/ml) and positive (2333 U/ml) β2 fraction in protein electrophoresis. In contrast, changes in the protein pattern of the β2 fraction were related to an inflammatory pattern with significantly higher C-reactive protein concentration (p<0.0001), independently of serum CA 19.9 level.
Conclusion:
The intensity of the β2 fraction in protein electrophoresis is related to inflammation and not to CA 19.9 in patients with cancer or other diseases.
Related Concept Videos
Serum Studies: Renal Function Tests
Nephrotic Syndrome II : Assessment and Medical Management
Serum Laboratory Studies, Stool Test, Breath Test

