Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Methods of Documentation VI: Case Management Model01:15

Methods of Documentation VI: Case Management Model

942
The case management model is a multidisciplinary approach that involves healthcare professionals from diverse disciplines, such as physicians, nurses, therapists, social workers, and pharmacists, working collaboratively to address the various needs of patients. Each healthcare professional brings unique expertise and perspectives, contributing to a more comprehensive understanding of the patient's condition and tailoring treatment plans accordingly.
For example, a patient with a chronic...
942
Mixing Concrete01:30

Mixing Concrete

382
Concrete mixing ensures a homogenous blend where aggregates are well-coated with cement paste. Concrete mixing is typically done using two main types of mixers: batch and continuous. Batch mixers handle one batch at a time, thoroughly combining materials before discharging and receiving the next batch. In contrast, continuous mixers receive a steady flow of ingredients, mixing them consistently and discharging without interruption. Within batch mixers, tilting drum mixers mix with internal...
382
Mixing Time01:19

Mixing Time

478
The concept of mixing time is significant in producing a uniform concrete mix with the required strength. The mixing period starts once all components are in the mixer. Initially, the mixer is charged with 10% of the water, followed by the consistent addition of solids and then 80% of the water. The remaining water is added later, within the first quarter of the mixing period. The minimum mixing time varies according to the mixer's capacity; for example, mixers with up to 1 cubic yard...
478
Ready Mixed Concrete01:26

Ready Mixed Concrete

365
Ready-mixed concrete, also known as pre-mixed concrete, is prepared in a centralized plant and then transported in trucks to construction sites where it is ready for placement. This type of concrete is categorized into central-mixed, truck-mixed (or transit-mixed), and shrink-mixed. Central-mixed concrete is entirely prepared at a plant and moved to the site in agitator trucks that rotate at a speed of 2 to 6 rpm. Truck-mixed concrete, on the other hand, has the ingredients batched at the plant...
365
Design Example: Vintage Mixing Console01:17

Design Example: Vintage Mixing Console

577
A sound engineer at a music company recently encountered a problem. The output from their newly acquired studio's vintage mixing console was too low for the requirements of modern recording equipment. To rectify this situation, the engineer decided to design an audio pre-amplifier using an operational amplifier (op-amp) to boost the signal level.
The specifications for the pre-amplifier were clear. It needed to amplify the audio signal by a factor of 10, have an input impedance above 10...
577
Tonsillitis II: Management01:26

Tonsillitis II: Management

428
This lesson will focus on the different treatment options for managing tonsillitis, which typically depend on the cause and severity.
428

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The GALENOS approach to triangulating evidence: a structured approach for integrating information from human and animal studies.

BMC medical research methodology·2026
Same author

The nexus between anxiety and depression.

The British journal of psychiatry : the journal of mental science·2026
Same author

Breaking down the ADHD construct to build a valid diagnosis.

Acta neuropsychiatrica·2026
Same author

Lithium: challenges of being king.

The British journal of psychiatry : the journal of mental science·2026
Same author

Gordon's penchant for ginning up controversy: A fetish for argumentation?

Australasian psychiatry : bulletin of Royal Australian and New Zealand College of Psychiatrists·2026
Same author

Automatically detecting trends and open questions from mental health publications: a Wellcome-funded GALENOS project.

BMJ mental health·2026
Same journal

Impact of Omaveloxolone on Serum Lipids in Patients with Friedreich Ataxia: A 1-Year Real-World Analysis.

CNS drugs·2026
Same journal

Emerging Pharmacological Strategies for Trigeminal Neuralgia.

CNS drugs·2026
Same journal

Psychiatric Symptoms Associated with Corticosteroid Use: A Systematic Review and Meta-analysis.

CNS drugs·2026
Same journal

Anti-CD20 Therapies in Pediatric Acquired Demyelinating Syndromes: Evidence Across MS, AQP4-IgG-Positive NMOSD and MOGAD.

CNS drugs·2026
Same journal

Isoform-Specific NaV Modulation in Painful Chemotherapy-Induced Neuropathy: Promise, Limitations, and a Clinical Agenda.

CNS drugs·2026
Same journal

Correction: Seletracetam Revisited: A Missed Opportunity for Effective Epilepsy Therapy.

CNS drugs·2026
See all related articles

Related Experiment Video

Updated: Jan 29, 2026

Development of an Individual-Tree Basal Area Increment Model using a Linear Mixed-Effects Approach
04:35

Development of an Individual-Tree Basal Area Increment Model using a Linear Mixed-Effects Approach

Published on: July 3, 2020

3.7K

Mixed States: Modelling and Management.

Gin S Malhi1,2,3, Kristina Fritz4, Preeya Elangovan5,6

  • 1Discipline of Psychiatry, Northern Clinical School, University of Sydney, Sydney, NSW, 2000, Australia. gin.malhi@sydney.edu.au.

CNS Drugs
|February 4, 2019
PubMed
Summary
This summary is machine-generated.

Mixed states, characterized by co-occurring manic and depressive symptoms, require a new conceptual framework. The proposed ACE model offers a novel approach to understanding and managing these complex mood disorder presentations.

More Related Videos

Interrogating Individual Autoreactive Germinal Centers by Photoactivation in a Mixed Chimeric Model of Autoimmunity
11:12

Interrogating Individual Autoreactive Germinal Centers by Photoactivation in a Mixed Chimeric Model of Autoimmunity

Published on: April 11, 2019

7.5K
Measuring and Mapping Patterns of Soil Erosion and Deposition Related to Soil Carbonate Concentrations Under Agricultural Management
08:09

Measuring and Mapping Patterns of Soil Erosion and Deposition Related to Soil Carbonate Concentrations Under Agricultural Management

Published on: September 12, 2017

12.3K

Related Experiment Videos

Last Updated: Jan 29, 2026

Development of an Individual-Tree Basal Area Increment Model using a Linear Mixed-Effects Approach
04:35

Development of an Individual-Tree Basal Area Increment Model using a Linear Mixed-Effects Approach

Published on: July 3, 2020

3.7K
Interrogating Individual Autoreactive Germinal Centers by Photoactivation in a Mixed Chimeric Model of Autoimmunity
11:12

Interrogating Individual Autoreactive Germinal Centers by Photoactivation in a Mixed Chimeric Model of Autoimmunity

Published on: April 11, 2019

7.5K
Measuring and Mapping Patterns of Soil Erosion and Deposition Related to Soil Carbonate Concentrations Under Agricultural Management
08:09

Measuring and Mapping Patterns of Soil Erosion and Deposition Related to Soil Carbonate Concentrations Under Agricultural Management

Published on: September 12, 2017

12.3K

Area of Science:

  • Psychiatry
  • Neuroscience
  • Clinical Psychology

Background:

  • Current understanding of mixed states (co-occurring manic and depressive symptoms) is insufficient for clinical practice and research.
  • The Diagnostic and Statistical Manual of Mental Disorders (DSM-5) no longer codes mixed state episodes, and the 'mixed features specifier' inadequately represents common presentations.
  • Limited research exists on the nature and pathophysiology of mixed states, with clinical guidelines lacking management advice.

Purpose of the Study:

  • To propose a reconceptualization of mixed states to guide clinical practice and research.
  • Introduce the Activity, Cognition, and Emotion (ACE) model as a framework for deconstructing mood disorders.
  • Provide a structured approach to understanding the etiology and management of mixed states.

Main Methods:

  • Deconstruction of mood disorders into three symptom domains: activity, cognition, and emotion (ACE model).
  • Explanation of mixed states as the result of asynchronous variations across these domains.
  • Identification of potential causes including idiopathic, transitions, ultradian cycling, and treatment-emergent affective switches.

Main Results:

  • The ACE model explains mixed states as 'out of sync' domain variations.
  • Identified idiopathic mixed states and three specific etiological categories relevant to management.
  • Outlined strategies for identifying and managing mixed states based on ACE domain monitoring and functioning.

Conclusions:

  • A reconceptualization of mixed states using the ACE model provides a framework for research and clinical practice.
  • Understanding mixed states requires considering asynchronous domain variations and specific etiological factors.
  • Practical management strategies involve monitoring ACE domains, functioning, and utilizing interventions like psychoeducation, psychotherapy, and pharmacotherapy.