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Rapid spread of mannan to the immune system, skin and joints within 6 hours after local exposure

C Hagert1,2, R Siitonen3, X-G Li3,4

  • 1Medical Inflammation Research, MediCity Research Laboratory, University of Turku, Turku, Finland.

Clinical and Experimental Immunology
|February 4, 2019
PubMed

Insights

Mannan, a common environmental polysaccharide, rapidly travels to joints and bone marrow after injection. This rapid transport may explain how mannan triggers inflammatory diseases like psoriasis and arthritis.

Area of Science:

  • Immunology
  • Biochemistry
  • Medical Imaging

Background:

  • Psoriasis (Ps), psoriatic arthritis (PsA), and rheumatoid arthritis (RA) are common inflammatory diseases.
  • Environmental factors are implicated in disease activation, but mechanisms remain unclear.
  • Mannan, a polysaccharide found in the environment, can induce Ps-, PsA-, and RA-like inflammation in mice.

Purpose of the Study:

  • To investigate the in-vivo transport and distribution of mannan in mice.
  • To understand the pathways of mannan uptake and excretion.

Main Methods:

  • Fluorine-18 ([18F])-labeled mannan was synthesized.
  • Positron emission tomography/computed tomography (PET/CT) was used to track [18F]fluoromannan distribution.
  • Mice received intraperitoneal injections of [18F]fluoromannan.

Main Results:

  • Mannan was rapidly transported to joints (knee) and bone marrow (tibia) within 6 hours post-injection.
  • Presence in blood and rapid distribution suggested cellular transport via the circulatory system.
  • Mannan was primarily filtered by the spleen and liver.
  • [18F]fluoromannan was excreted through the kidneys, small intestine, and mouth.

Conclusions:

  • Mannan rapidly reaches joint tissues after administration.
  • The rapid joint targeting of mannan provides a potential explanation for its role in inducing localized inflammatory diseases in these tissues.
Keywords:
[18F]fluoromannanarthritisbiodistributionpsoriasispsoriatic arthritis

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