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Association of Serum Osmolarity With Contrast-Induced Nephropathy in Patients With ST-Segment Elevation Myocardial

Ibrahim Yildiz1, Pinar Ozmen Yildiz1, Ibrahim Rencuzogullari2

  • 11 Department of Cardiology, Osmaniye State Hospital, Osmaniye, Turkey.

Angiology
|February 5, 2019
PubMed

Insights

Serum osmolarity, a simple blood test, can predict contrast-induced nephropathy (CIN) in ST-elevation myocardial infarction (STEMI) patients undergoing primary percutaneous coronary intervention (pPCI). Higher osmolarity indicates increased risk for developing CIN after the procedure.

Area of Science:

  • Nephrology
  • Cardiology
  • Clinical Chemistry

Background:

  • Contrast-induced nephropathy (CIN) is a significant complication following primary percutaneous coronary intervention (pPCI).
  • The relationship between serum osmolarity and chronic kidney disease is known, but its role in CIN for ST-segment elevation myocardial infarction (STEMI) patients undergoing pPCI requires further investigation.

Purpose of the Study:

  • To evaluate the predictive capability of serum osmolarity for CIN development in STEMI patients undergoing pPCI.
  • To identify key predictors of CIN in this patient cohort.

Main Methods:

  • A study involving 768 STEMI patients undergoing pPCI was conducted.
  • Serum osmolarity was calculated upon admission.
  • Patients were categorized into groups based on CIN development and compared using clinical, laboratory, and demographic data.

Main Results:

  • Patients who developed CIN had significantly higher serum osmolarity compared to those who did not (278 [8] vs 284 [9]; P = .024).
  • Independent predictors of CIN included serum osmolarity (OR: 1.052; 95% CI: 1.018-1.086; P = .002), hemoglobin, contrast media volume, admission creatinine, SYNergy between PCI with TAXus and cardiac surgery II score, and left ventricular ejection fraction.

Conclusions:

  • Serum osmolarity is a significant independent predictor of CIN in STEMI patients undergoing pPCI.
  • The simple calculation of serum osmolarity on admission can aid in identifying patients at higher risk of developing CIN.

Keywords:
ST-elevation myocardial infarctioncontrast-induced nephropathyosmolaritypercutaneous coronary intervention

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