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Updated: Jan 29, 2026
08:02
Mouse Model of Surgically-induced Endometriosis by Auto-transplantation of Uterine Tissue
Published on: January 6, 2012
29.7K
Uterine transplantation
1a Department of Obstetrics & Gynecology , University of British Columbia , Vancouver , BC , Canada.
Climacteric : the Journal of the International Menopause Society
|February 5, 2019
Summary
Uterine transplantation enables pregnancy for women unable to conceive. While successful live births have occurred, the procedure poses risks to live donors, prompting exploration of deceased donors and surgical modifications.
Area of Science:
- Reproductive medicine
- Transplant surgery
Background:
- Human uterine transplantation aims to enable pregnancy in women with uterine factor infertility.
- Pioneering programs have reported successful live births, with most transplants from live donors.
Purpose of the Study:
- To review the current status and challenges of human uterine transplantation.
- To explore alternative donor sources and procedural modifications.
Main Methods:
- Review of published outcomes from uterine transplantation programs worldwide.
- Discussion of donor types (live vs. deceased) and surgical considerations.
Main Results:
- Multiple live births have been achieved following uterine transplantation.
- Live donor procedures are invasive and carry risks; deceased donor transplants are being explored.
- Technical modifications are being investigated to simplify the surgery.
Conclusions:
- Uterine transplantation is an experimental procedure with ongoing ethical, technical, financial, and social considerations.
- Alternative options like gestational carriers and adoption remain important considerations for patients.
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