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[Renal transplantation in the child]
1Service de Néphrologie Pédiatrique, Hôpital des Enfants-Malades, Paris.
Archives Francaises De Pediatrie
|January 1, 1988
Summary
Pediatric kidney transplantation has excellent survival rates, with nearly 100% patient survival since 1985, especially with cyclosporine. This improves quality of life and growth in children with renal grafts.
Area of Science:
- Pediatric Nephrology
- Transplantation Immunology
- Surgical Innovation
Context:
- In Europe, by Dec 31, 1986, 50% of 1,616 registered children (<15 years) had functional renal grafts.
- Living donor transplants (5%) bypassed pre-transplant dialysis, while brain-dead donor recipients often faced long dialysis waits.
- Recipient preparation, legal aspects, and selection criteria for cadaveric kidney grafts in children were detailed.
Purpose:
- To review the process and outcomes of kidney transplantation in pediatric patients.
- To highlight the impact of cyclosporine on graft survival and patient well-being.
- To discuss surgical techniques, perioperative care, and long-term results, including rehabilitation and growth.
Summary:
- Renal transplantation in children has shown remarkable improvement since 1985, with nearly 100% patient survival attributed to cyclosporine.
- Second transplantations after graft failure yield comparable or superior results.
- Cyclosporine therapy also offers better statural growth prospects compared to older immunosuppressors.
Impact:
- Improved long-term quality of life, rehabilitation, and social/professional integration for pediatric kidney transplant recipients.
- Enhanced growth potential in children undergoing renal transplantation with modern immunosuppressive regimens.
- Established kidney transplantation as a highly successful treatment for pediatric end-stage renal disease.