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Related Experiment Videos

[Intestinal transplantation in children].

O Goulet1, Y Revillon, C Nezelof

  • 1Département de Pédiatrie, Hôpital des Enfants-Malades, Paris.

Archives Francaises De Pediatrie
|January 1, 1988
PubMed
Summary

Experimental work in intestinal transplantation, including hypothermic preservation and allotransplantation, has advanced human procedures. Indications include pediatric subtotal resections, but the small bowel presents unique challenges requiring further research.

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Area of Science:

  • Surgical Innovation
  • Organ Transplantation
  • Immunosuppression

Context:

  • Extensive experimental research in small bowel preservation, autotransplantation, and allotransplantation preceded human trials.
  • The advent of cyclosporine enabled the initiation of human intestinal transplantation procedures.
  • Recent clinical experience includes three intestinal transplantations performed by a Paris-based surgical group.

Purpose:

  • To report on recent human intestinal transplantations.
  • To outline the primary indications for intestinal transplantation.
  • To highlight the complexities and ongoing challenges in small bowel transplantation.

Summary:

  • Indications for intestinal transplantation primarily involve subtotal small bowel resections in pediatric and adolescent patients, and extensive resections in neonates.

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  • The small bowel is noted to encapsulate many difficulties encountered in other organ transplantations, underscoring its complexity.
  • Despite progress, the field requires further advancements to overcome the unique challenges associated with intestinal transplantation.
  • Impact:

    • Advances in experimental surgery and immunosuppression have paved the way for clinical intestinal transplantation.
    • Established indications provide guidance for patient selection in complex gastrointestinal surgical cases.
    • Recognizing the small bowel's unique challenges stimulates further research and development in transplantation medicine.