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Tranylcypromine and 6-trifluoroethyl thienopyrimidine hybrid as LSD1 inhibitor

Xiaowen Wang1, Mingbo Su2, You Li3

  • 1College of Chemistry, Chemical Engineering and Environmental Engineering, Liaoning Shihua University, Dandong Lu West 1, Fushun 113001, PR China; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, PR China.

Bioorganic & Medicinal Chemistry Letters
|February 5, 2019
PubMed

Keywords:
LSD1 inhibitorMV4-11 antiproliferative activityMenin-MLL1 protein-protein interaction inhibitorStructure activity relationshipTranylcypromine

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