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A Piglet Model of Neonatal Hypoxic-Ischemic Encephalopathy
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Levofloxacin-associated Encephalopathy with Severe Hyperventilation.

Mieko Sugiura1, Koichi Shibata1, Satoshi Saito1

  • 1Department of Internal Medicine, Tokyo Women's Medical University Medical Center East, Japan.

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PubMed
Summary
This summary is machine-generated.

A rare case of levofloxacin-associated encephalopathy caused severe psychosis and hyperventilation. Symptoms resolved after discontinuing the antibiotic, highlighting a potential adverse effect.

Keywords:
antibiotic-associated encephalopathycentral nervous system toxicityhyperventilationlevofloxacinpsychosis

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Area of Science:

  • Neurology
  • Pharmacology

Background:

  • Levofloxacin is a fluoroquinolone antibiotic commonly prescribed for bacterial infections.
  • Adverse drug reactions can range from mild to severe, impacting neurological function.

Observation:

  • A 64-year-old woman developed acute psychosis, involuntary movements, and hyperventilation with respiratory alkalosis two hours after a single 500 mg dose of levofloxacin for cystitis.
  • Neurological imaging and electroencephalogram were unremarkable.

Findings:

  • Levofloxacin discontinuation led to symptom improvement within three days.
  • The adverse event suggests levofloxacin-induced encephalopathy with psychotic features and hyperventilation.

Implications:

  • Levofloxacin may disrupt gamma-aminobutyric acid-ergic (GABAergic) interneurons, potentially causing brainstem respiratory network dysfunction.
  • Physicians should consider hyperventilation as a significant symptom of levofloxacin-associated encephalopathy.