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Updated: Jan 29, 2026
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Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma
Published on: November 4, 2010
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Bronchial Thermoplasty for Severe Asthma with Mucus Hypersecretion
Naoko Nagano1, Motoyasu Iikura1, Ayaka Ito1
1Department of Respiratory Medicine, National Center for Global Health and Medicine, Japan.
Internal Medicine (Tokyo, Japan)
|February 5, 2019
Summary
Bronchial thermoplasty (BT) improved severe asthma control and quality of life in a patient. Histology confirmed reduced airway inflammation and smooth muscle mass after the radiofrequency treatment.
Area of Science:
- Pulmonary Medicine
- Interventional Pulmonology
Background:
- Severe persistent uncontrolled asthma poses significant challenges.
- Bronchial thermoplasty (BT) is an option for refractory asthma.
- Radiofrequency energy targets the bronchial wall to reduce airway smooth muscle.
Observation:
- A 47-year-old male patient with severe uncontrolled asthma underwent BT.
- The patient experienced improvements in asthma control and quality of life post-procedure.
- Pulmonary function tests indicated positive changes after BT.
Findings:
- Histologic analysis of transbronchial biopsies showed decreased goblet cell hyperplasia.
- A reduction in bronchial smooth muscle mass was observed.
- Subepithelial basement membrane thickness also decreased following BT.
Implications:
- Bronchial thermoplasty demonstrates efficacy in severe asthma with mucus hypersecretion.
- BT may offer a therapeutic option for reducing airway remodeling in severe asthma.
- This case highlights the potential benefits of BT for improving patient outcomes.
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