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Updated: Aug 4, 2026

Accurate and Simple Measurement of the Pro-inflammatory Cytokine IL-1β using a Whole Blood Stimulation Assay
06:29

Accurate and Simple Measurement of the Pro-inflammatory Cytokine IL-1β using a Whole Blood Stimulation Assay

Published on: March 1, 2011

Hematopoietic activities of interleukin 1

C S Henney1

  • 1Immunex Corporation, Seattle, Washington 98101.

Behring Institute Mitteilungen
|August 1, 1988
PubMed

IL-1 is perhaps the most pleiomorphic of the cytokines. Only recently however has it been suspected that IL-1 has effects in stimulating hematopoiesis. Its principal effect in this regard seems to be stimulation of pluripotent stem cells, causing these cells to then respond to lineage-specific growth factors. Thus, although IL-1 does not function directly as a colony stimulating factor, it synergizes with G-CSF, GM-CSF, and IL-3. Indeed, biochemical and serological evidence suggests that IL-1 accounts totally for the biological activity previously termed hemopoietin-1 which has been shown to play a central role in the regulation of hematopoiesis.

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