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In vivo Structural Assessments of Ocular Disease in Rodent Models using Optical Coherence Tomography
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Nano-optic endoscope for high-resolution optical coherence tomography in vivo
Hamid Pahlevaninezhad1,2, Mohammadreza Khorasaninejad2, Yao-Wei Huang2,3
1Harvard Medical School and Massachusetts General Hospital, Boston MA 02114, United States.
Nature Photonics
|February 5, 2019
Summary
A novel nano-optic endoscope uses a metalens to overcome optical aberrations and improve image depth-of-focus for internal organ imaging. This advancement enhances the clinical utility of endoscopic optical imaging.
Area of Science:
- Biomedical Optics
- Medical Imaging
- Nanotechnology
Background:
- Endoscopic optical imaging offers clinical potential but is limited by optical aberrations and resolution-depth trade-offs.
- Existing methods struggle to achieve high-resolution imaging deep within internal organs.
Purpose of the Study:
- To develop an endoscopic optical coherence tomography catheter with enhanced imaging capabilities.
- To overcome limitations of transverse resolution and depth-of-focus in endoscopic imaging.
Main Methods:
- Integration of a metalens into an endoscopic optical coherence tomography catheter (nano-optic endoscope).
- Utilizing the metalens' phase modulation and tailored chromatic dispersion for aberration correction.
- Employing spectral interferometry to maintain high-resolution imaging beyond the Rayleigh range.
Main Results:
- Achieved near diffraction-limited imaging by negating non-chromatic aberrations.
- Extended high-resolution imaging depth-of-focus, mitigating the resolution-depth trade-off.
- Demonstrated successful endoscopic imaging in human lung specimens and live sheep airways.
Conclusions:
- The nano-optic endoscope significantly improves image resolution and depth-of-focus.
- This technology enhances the clinical applicability of endoscopic optical imaging.
- Metalens integration represents a significant advancement in endoscopic imaging technology.
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