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Related Experiment Videos

Changes in Verbal Fluency in Parkinson's Disease.

Liana S Rosenthal1, Yekaterina A Salnikova1, Gregory M Pontone2

  • 1Department of Neurology Johns Hopkins University School of Medicine Baltimore Maryland USA.

Movement Disorders Clinical Practice
|February 5, 2019
PubMed
Summary

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Semantic verbal fluency decline in Parkinson's disease (PD) is linked to longer disease duration, older age, and comorbidities like cardiovascular disease and psychiatric symptoms. Monitoring fluency can identify patients at risk for reduced quality of life.

Area of Science:

  • Neurology
  • Cognitive Science

Background:

  • Semantic verbal fluency testing is a simple measure for assessing executive function.
  • Declines in semantic verbal fluency can indicate executive dysfunction in Parkinson's disease (PD).

Purpose of the Study:

  • To analyze the annual rate of verbal fluency change in individuals with Parkinson's disease (PD).
  • To identify determinants of verbal fluency changes in PD patients.
  • To explore the relationship between verbal fluency, clinical characteristics, quality of life, and caregiver burden.

Main Methods:

  • Analysis of data from the National Parkinson Foundation's Outcomes Project, including baseline and two annual follow-up visits.
  • Utilized linear mixed modeling to assess associations between verbal fluency and various patient factors.
Keywords:
CognitionParkinson's diseaseverbal fluency

Related Experiment Videos

  • Included 1,322 participants with an average age of 67.3 years and an average PD duration of 8.4 years.

    • Main Results:

    • Verbal fluency scores remained stable in the average patient but decreased with longer PD duration, older age, Hoehn and Yahr stage >=3, cardiovascular disease, and psychiatric symptomatology.
    • Specifically, longer PD duration (beta = -0.25; P = 0.03), older age (beta = -0.022; P < 0.01), Hoehn and Yahr >=3 (beta = -0.31; P = 0.04), cardiovascular disease (beta = -0.32; P = 0.01), and psychiatric symptomatology (beta = -0.34; P = 0.01) were associated with decreased verbal fluency.
    • Higher baseline verbal fluency scores correlated with better quality of life (P < 0.01) and reduced caregiver burden (P < 0.01).

    Conclusions:

    • Verbal fluency monitoring is recommended for evaluating cognitive decline in Parkinson's disease (PD) patients.
    • Psychiatric symptomatology and cardiovascular disease are modifiable risk factors impacting verbal fluency.
    • Verbal fluency testing can help identify individuals at risk for diminished quality of life and increased caregiver burden, enabling targeted interventions.