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Serum catestatin concentrations are decreased in obese children and adolescents
Marko Simunovic1, Daniela Supe-Domic2, Zeljka Karin3
1Department of Pediatrics, University Hospital of Split, Split, Croatia.
Insights
Obese children and adolescents have lower catestatin levels, especially those with metabolic syndrome (MS). Lower catestatin is linked to increased cardiovascular risk factors in this pediatric group.
Area of Science:
- Endocrinology
- Pediatrics
- Cardiovascular Risk Assessment
Background:
- Catestatin, a peptide derived from chromogranin A, exhibits diverse biological functions including regulation of catecholamine release and blood pressure.
- Its role in pediatric obesity and associated metabolic complications remains largely unexplored.
Purpose of the Study:
- To investigate serum catestatin concentrations in obese children and adolescents.
- To examine the relationship between catestatin levels, metabolic syndrome (MS), and cardiovascular risk factors in this population.
Main Methods:
- Enzyme-linked immunosorbent assay (ELISA) was employed to quantify serum catestatin levels.
- Comparison of catestatin concentrations between obese subjects (n=92) and normal-weight controls (n=39).
- Correlation analysis was performed to assess associations with cardiovascular risk markers.
Main Results:
- Obese subjects exhibited significantly lower serum catestatin concentrations compared to controls (10.03 ± 5.05 vs. 13.13 ± 6.25 ng/mL, P=0.004).
- Obese individuals with MS showed even lower catestatin levels than obese subjects without MS and controls (9.02 ± 4.3 vs. 10.54 ± 5.36 vs. 13.13 ± 6.25 ng/mL, P=0.008).
- Catestatin levels were negatively correlated with diastolic blood pressure, insulin resistance (HOMA-IR), and high-sensitivity C-reactive protein.
Conclusions:
- This study is the first to report reduced catestatin concentrations in obese children and adolescents.
- Lower catestatin levels are associated with metabolic syndrome and elevated cardiovascular risk factors in the pediatric population.
- Catestatin may serve as a potential biomarker for metabolic dysfunction and cardiovascular risk in obese youth.
Background:
Catestatin is a chromogranin A-derived peptide with a wide spectrum of biological activities, such as inhibiting catecholamine release, decreasing blood pressure, stimulating histamine release, reducing beta-adrenergic stimulation, and regulating oxidative stress.
Objectives:
The aims of our study were to determine serum catestatin concentrations in obese children and adolescents in regard to presence or absence of metabolic syndrome (MS) and to evaluate the possible relations between catestatin levels and other cardiovascular risk factors.
Subjects:
Ninety-two obese subjects with a body mass index z score > 2, aged 10 to 18 years, and 39 healthy, normal weight controls were enrolled in the study.
Methods:
Serum catestatin concentrations were measured using an enzyme-linked immunosorbent assay.
Results:
Significantly lower serum catestatin concentrations were recorded in the group of obese subjects compared with a control group (10.03 ± 5.05 vs 13.13 ± 6.25 ng/mL, P = 0.004). Further analyses revealed significantly lower catestatin concentrations in the subgroup of obese patients with MS (9.02 ± 4.3 vs 10.54 ± 5.36 vs 13.13 ± 6.25, P = 0.008). Serum catestatin concentrations were significantly negatively correlated with diastolic blood pressure (r = -0.253, P = 0.014), homeostatic model assessment of insulin resistance (r = -0.215, P = 0.037) and high sensitivity C-reactive protein (r = -0.208, P = 0.044).
Conclusions:
To the best of our knowledge, this study is the first to report catestatin concentrations in obese children and adolescents and their possible relations with MS and cardiovascular risk factors in a pediatric population. Obese subjects with MS have lower serum catestatin concentrations than obese subjects without MS and controls.
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