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Association between polymorphisms in CXCR2 gene and preeclampsia.
Hongqin Chen1, Yanping Zhang1, Li Dai1
1Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University) of Ministry of Education, Chengdu, Sichuan, PR China.
Molecular Genetics & Genomic Medicine
|February 5, 2019
Summary
Genetic variations in the CXCR2 gene, specifically the rs1126579 polymorphism, are linked to an increased risk of preeclampsia in Chinese women. This finding offers new insights into the genetic factors contributing to this pregnancy complication.
Area of Science:
- Genetics and Genomics
- Obstetrics and Gynecology
- Molecular Biology
Background:
- Preeclampsia is a serious pregnancy-specific condition with unclear causes.
- Reduced expression of CXCR2 in preeclamptic placentas suggests a potential role in disease development.
- The impact of CXCR2 gene single nucleotide polymorphisms (SNPs) on preeclampsia pathogenesis is not well understood.
Purpose of the Study:
- To investigate the association between polymorphisms in the CXCR2 gene and preeclampsia.
- To explore the role of specific CXCR2 gene variants (rs1126579 and rs2230054) in Han Chinese women with preeclampsia.
Main Methods:
- A case-control study involving 481 pregnant women (238 preeclampsia patients, 243 controls).
- Genotyping of rs1126579 and rs2230054 polymorphisms in the CXCR2 gene.
- Utilized the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method for genotyping.
Main Results:
- The rs1126579 CC or TC/CC genotypes were associated with a significantly increased risk of preeclampsia compared to the TT genotype (OR=2.11, p=0.039; OR=1.89, p=0.001).
- The rs1126579 TC genotype showed a higher risk of preeclampsia (OR=1.48, p=0.031).
- Genotype distributions were particularly significant in severe preeclampsia, early-onset severe preeclampsia, and late-onset severe preeclampsia groups, with TC genotype carriers showing elevated risks.
Conclusions:
- A significant genetic association exists between the rs1126579 polymorphism in the CXCR2 gene and an elevated risk of preeclampsia.
- These findings suggest that specific CXCR2 gene variants may contribute to preeclampsia development.
- Further research is warranted to elucidate the precise mechanisms underlying this genetic association.
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