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Updated: Jan 29, 2026

Solid Phase Synthesis of a Functionalized Bis-Peptide Using "Safety Catch" Methodology
Published on: May 15, 2012
Synthesis, Isolation, and Characterization of Mono- and Bis-norbornene-Annulated Biarylamines through
Pratheepkumar Annamalai1, Huan-Chang Hsiao1, Selvam Raju1
1Department of Applied Chemistry , National Chiao Tung University , Hsinchu 30010 , Taiwan.
Abstract:
A palladium-catalyzed C-H functionalization of an external ring of N-acyl 2-aminobiaryl with bicyclo[2.2.1]hept-2-ene (norbornene) via multiple C-H bond activations was developed. This study is the first report of the formation of bis-norbornene annulated biarylamines isomers ( syn-3a'/ anti-3a' = 36:64) from multiple C-H bond functionalizations. Additionally, nondirected C-H bond functionalization at the C-4' position with alkenes rendered complete C-H functionalization of five C-H bonds that formed a stable hexasubstituted benzene ring.
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