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The Potential Role of Dysregulated miRNAs in Alzheimer's Disease Pathogenesis and Progression
Ankur A Patel1, Ganepola A P Ganepola1, John R Rutledge2
1Department of Research, Center for Cancer Research and Genomic Medicine, The Valley Hospital, Paramus, NJ, USA.
Abstract:
Alzheimer's disease (AD) is a debilitating neurodegenerative disease that affects the cognitive faculties of millions of people worldwide. There is still no known cure for AD, nor a clear understanding of AD etiology. Nevertheless, researchers have made significant strides in understanding various key aspects of AD neuropathology at the cellular and molecular levels. This review is intended to provide a general survey of what is known and unknown, based on the three hallmarks of AD, combined with our knowledge from microRNA research. Our goal is to reevaluate and reassess the current direction of AD research and therapeutic insights, charting a new course and comprehensive plan to combat this imminent global health threat.