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GLAD: GLycan Array Dashboard, a visual analytics tool for glycan microarrays.

Akul Y Mehta1, Richard D Cummings1

  • 1National Center for Functional Glycomics, Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.

Bioinformatics (Oxford, England)
|February 5, 2019
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Summary

Glycan microarray data analysis is challenging due to limited visualization. The GLAD dashboard offers a web-based solution for interactive glycan array data mining and comparison.

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Area of Science:

  • Carbohydrate chemistry
  • Bioinformatics
  • Data visualization

Background:

  • Glycan microarray data is traditionally stored in Excel files, hindering effective analysis and comparison.
  • Limited visualization and interactivity of existing glycan array data formats impede comprehensive data mining.

Purpose of the Study:

  • To develop a web-based tool, GLAD (GLycan Array Dashboard), for enhanced visualization, analysis, and data mining of glycan microarray data.
  • To overcome the limitations of traditional glycan array data presentation and facilitate easier comparison across multiple datasets.

Main Methods:

  • GLAD is a web-based application accessible via modern browsers.
  • It accepts multiple glycan microarray data files for comparative analysis.
  • Features include interactive visualization tools such as grouped bar charts, heatmaps, calendar heatmaps, force graphs, and correlation maps.

Main Results:

  • GLAD enables users to input and compare multiple glycan microarray datasets.
  • The tool provides diverse comparative visualizations to analyze extensive sample sets.
  • Interactive features for filtering, sorting, normalizing data, and viewing glycan structures enhance data mining efficiency.

Conclusions:

  • GLAD significantly improves the accessibility and analytical capabilities for glycan microarray data.
  • The interactive dashboard facilitates faster and more comprehensive visual data mining.
  • GLAD is freely available online, promoting wider adoption in glycomics research.