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Updated: Jan 29, 2026

Full-root Aortic Valve Replacement by Stentless Aortic Xenografts in Patients with Small Aortic Roots
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Eculizumab therapy in paroxysmal nocturnal haemoglobinuria patient undergoing aortic valve surgery

Sho Kusadokoro1, Naoyuki Kimura1, Daijiro Hori1

  • 1Department of Cardiovascular Surgery, Saitama Medical Center, Jichi Medical University, Saitama, Japan.

Interactive Cardiovascular and Thoracic Surgery
|February 5, 2019
PubMed

Paroxysmal nocturnal haemoglobinuria is a rare disorder characterized by haemolytic anaemia and pancytopaenia. The use of cardiopulmonary bypass can lead to a haemolytic crisis in patients with paroxysmal nocturnal haemoglobinuria due to activation of complement-mediated haemolysis. We report the successful management of a 69-year-old man undergoing aortic valve replacement with standard heparin-protamine protocol by using eculizumab, a monoclonal antibody of complement factor C5. The surgery was performed without triggering a haemolytic crisis, and the patient was discharged from the hospital without major complications.

Keywords:
Aortic valve replacementEculizumabParoxysmal nocturnal haemoglobinuria

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