Related Experiment Video
Updated: Jan 29, 2026
Hemodynamic Precision in the Neonatal Intensive Care Unit using Targeted Neonatal Echocardiography
Published on: January 27, 2023
A Comparison of Point of Care C-Reactive Protein Test to Standard C-Reactive Protein Laboratory Measurement in a
Kim Prince1, Fierdoz Omar2, Yaseen Joolay1
1Neonatal Medicine, Department of Paediatrics, University of Cape Town, Cape Town, South Africa.
Background:
Biomarkers assist in diagnosing neonatal sepsis but often provide results 6 to 48 h later. Bedside C-reactive protein (CRP) test may help to expedite clinical management. We assessed the performance of point of care test (POCT) CRP against routine laboratory analysis and determined the time difference in obtaining results.
Methods:
A prospective observational study was conducted over 4 months. Neonates clinically indicated, had CRP simultaneously tested using the POCT and laboratory assays.
Results:
Using similar decision cut-off values of 10 mg/l, POCT compared favourably to laboratory testing. The median times to POCT result was 4 min whereas laboratory results were entered at a median of 4.1 h (95th percentile 8 h) but only checked after 5.5 h (95th percentile 19.8 h).
Conclusions:
POCT may be a quick and reliable method to determine CRP. It may rationalize antibiotic usage, allow for earlier patient discharge and reduce overall patient management cost.
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