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Related Concept Videos

Neurons: The Cell Body and the Dendrites01:23

Neurons: The Cell Body and the Dendrites

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A typical nerve cell comprises three main components: the cell body, dendrites, and the axon. The cell body, also known as the soma or perikaryon, serves as the central biosynthetic hub housing a nucleus surrounded by cytoplasm containing organelles commonly found in most cells. Notably, Nissl bodies, clusters of the rough endoplasmic reticulum and free ribosomes responsible for protein synthesis, are distinctive features of the neuronal cell body. As neurons age, aggregates of a brown pigment...
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What are Cells?01:07

What are Cells?

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Cells are the smallest and basic units of life, whether it is a single cell that forms the entire organism, e.g., in a bacterium or trillions of them, e.g., in humans. No matter what organism a cell is a part of, they share specific characteristics.
Basic Characteristics of Cells
A living cell has a plasma membrane, a bilayer of lipids that separates the aqueous solution inside the cell called the cytoplasm from the outside environment.
Furthermore, a living cell possesses genetic information...
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What is Cell Signaling?02:03

What is Cell Signaling?

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Despite the protective membrane that separates a cell from the environment, cells need the ability to detect and respond to environmental changes. Additionally, cells often need to communicate with one another. Unicellular and multicellular organisms use a variety of cell signaling mechanisms to communicate to respond to the environment.
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Concentration Cells02:41

Concentration Cells

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A concentration cell is a type of a  voltaic cell constructed by connecting two almost identical half-cells, both based on the same half-reaction and using the same electrode, differing only in the concentration of one redox species. A concentration cell's potential, therefore, is determined only by the concentration difference of the particular redox species.
Consider the following voltaic cell:
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Chemistry of the Cell02:58

Chemistry of the Cell

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The cell is chemically composed of water, organic molecules and inorganic ions.
Water
The polarity of the water molecule and its resulting hydrogen bonding makes water a unique substance with special properties that are intimately tied to the processes of life. Life originally evolved in an aqueous environment, and most of an organism’s cellular chemistry and metabolism occur inside the aqueous contents of the cell’s cytoplasm. Special properties of water are its high heat capacity...
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Hair Cells01:22

Hair Cells

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Hair cells are the sensory receptors of the auditory system—they transduce mechanical sound waves into electrical energy that the nervous system can understand. Hair cells are located in the organ of Corti within the cochlea of the inner ear, between the basilar and tectorial membranes. The actual sensory receptors are called inner hair cells. The outer hair cells serve other functions, such as sound amplification in the cochlea, and are not discussed in detail here.
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Related Experiment Video

Updated: Jan 29, 2026

Fluorescence-activated Cell Sorting for Purification of Plasmacytoid Dendritic Cells from the Mouse Bone Marrow
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Blastic Plasmacytoid Dendritic Cell Neoplasm.

Daniel Kerr1, Ling Zhang2, Lubomir Sokol3

  • 1Department of Hematology and Medical Oncology, Moffitt Cancer Center/University of South Florida, 12902 USF Magnolia Dr, Tampa, FL, 33612, USA. Daniel.kerr@moffitt.org.

Current Treatment Options in Oncology
|February 5, 2019
PubMed
Summary
This summary is machine-generated.

New targeted therapies targeting CD123 show promise for blastic plasmacytoid dendritic cell neoplasm (BPDCN). These treatments may offer durable responses, especially for elderly or frail patients ineligible for stem cell transplantation.

Keywords:
BPDCNBone marrow transplantCD123LeukemiaSL-401Venetoclax

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Area of Science:

  • Hematology
  • Oncology
  • Immunotherapy

Background:

  • Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is an aggressive hematologic malignancy with poor outcomes.
  • Standard treatments like chemotherapy and stem cell transplantation (alloHSCT) have limitations, especially for elderly or frail patients.
  • CD123 is a promising therapeutic target expressed on BPDCN cells.

Purpose of the Study:

  • To review the current treatment landscape for BPDCN.
  • To evaluate the potential of novel CD123-targeted therapies for BPDCN management.
  • To discuss the implications of these therapies for different patient populations.

Main Methods:

  • Review of current literature and clinical trial data on BPDCN treatments.
  • Focus on CD123-targeted agents, including SL-401 and CAR-T therapy.
  • Analysis of treatment efficacy, toxicity, and applicability to various patient groups.

Main Results:

  • SL-401 demonstrates promising efficacy with manageable toxicity and durable responses, particularly for transplant-ineligible patients.
  • Chimeric antigen receptor T-cell (CAR-T) therapy targeting CD123 shows potential in ongoing trials.
  • Current data supports alloHSCT as the optimal consolidation for eligible patients.

Conclusions:

  • CD123-targeted therapies represent a significant advancement in BPDCN treatment.
  • These novel agents offer new hope for elderly or frail patients.
  • Future research should explore combination therapies and the potential to avoid transplant with CD123-directed treatments.