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Intra-Peritoneal Transplantation for Generating Acute Myeloid Leukemia in Mice
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New Treatment Options for Acute Myeloid Leukemia in 2019

Marco Cerrano1,2, Raphael Itzykson3,4,5

  • 1Department of Hematology, Hopital Saint-Louis, Assistance Publique Hopitaux de Paris, Paris Diderot University, Paris, France.

Current Oncology Reports
|February 5, 2019
PubMed
Abstract

Insights

New targeted therapies are transforming acute myeloid leukemia (AML) treatment. Approved drugs and promising agents, including FLT3 and IDH inhibitors, offer new hope for AML patients.

Area of Science:

  • Hematology
  • Oncology
  • Genomics

Background:

  • Acute myeloid leukemia (AML) genomic characterization has identified numerous therapeutic targets.
  • Recent advancements have led to the approval of novel targeted therapies for AML.

Purpose of the Study:

  • To review data supporting new targeted therapies in AML.
  • To discuss promising drugs currently in development for AML.

Main Methods:

  • Review of clinical trial data and published literature.
  • Analysis of recent drug approvals and ongoing clinical investigations.

Main Results:

  • New formulations of cytotoxic agents (CPX-351, gemtuzumab ozogamicin) improve outcomes in specific AML subgroups.
  • Midostaurin is approved for FLT3-mutated AML when added to chemotherapy.
  • Selective FLT3 inhibitors and IDH inhibitors (enasidenib, ivosidenib) show efficacy in relapsed AML.
  • BCL2 inhibitor venetoclax combined with hypomethylating agents shows promising results.

Conclusions:

  • The AML therapeutic landscape now includes novel cytotoxic drugs, oncogene-targeted agents, and drugs targeting leukemic vulnerabilities.
  • Further research is needed to optimize the integration of these new therapies into AML management, including allogeneic stem cell transplantation.
Keywords:
Acute myeloid leukemiaBCL2 inhibitorsFLT3 inhibitorsHypomethylating agentsIDH inhibitorsTargeted therapy

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