Related Experiment Video
Updated: Jan 29, 2026

Bioelectric Analyses of an Osseointegrated Intelligent Implant Design System for Amputees
Published on: July 15, 2009
Effects of micro/nano strontium-loaded surface implants on osseointegration in ovariectomized sheep
Fuwei Liu1, Yongfeng Li2, Jianfei Liang1
1State Key Laboratory of Military Stomatology and National Clinical Research Center for Oral Diseases and Shaanxi Clinical Research Center for Oral Diseases, Department of Oral and Maxillofacial Surgery, School of Stomatology, The Fourth Military Medical University, Xi'an, People's Republic of China.
Background:
Poor osseointegration of dental implants often occurs in osteoporotic patients and processed implant surfaces could help to improve the dilemma.
Purpose:
This study aimed to compare the effects of different titanium (Ti) surfaces on bone-implant osseointegration in ovariectomized (OVX) sheep.
Materials And Methods:
Four groups were included: smooth titanium (ST) was merely polished Ti; micro titanium (MT) was treated with hydrofluoric acid (HF) for 30 minutes; strontium-loaded nano titanium (NT-Sr) was formed by magnetron sputtering; strontium-loaded micro/nano titanium (MNT-Sr) was fabricated by HF etching combined with magnetron sputtering. The biological responses were evaluated by human bone marrow-derived mesenchymal stem cells (hBMMSCs) experiments in vitro. Osseointegration was evaluated in vivo after each surface implant was inserted into OVX sheep' mandibles.
Results:
The numbers of adhered and mineralized hBMMSCs increased significantly in the MNT-Sr group. The bone-implant contact and the maximal pull-out force increased significantly with MNT-Sr surface. The bone volume ratio and trabecular number of the MNT-Sr group were significantly higher than others, whereas trabecular separation decreased.
Conclusions:
These results indicated that an MNT-Sr surface promotes the differentiation of hBMMSCs in vitro and enhances bone-implant osseointegration in vivo, which may be a promising option for clinical implants in osteoporotic patients.
Related Concept Videos
Cloning of Dolly the Sheep
Factors Affecting Dissolution: Particle Size and Effective Surface Area
Impact Loading
In cases of elastic deformation,...
Distributed Loads
For example, consider a bookshelf filled with books stacked vertically adjacent to each other. The weight of the books is evenly distributed over the length of the shelf. As a result, the pressure at different locations on the surface of the...
Eccentric Loading
Buffer Effectiveness
The buffer capacity is the amount of acid or base that can be added to a given volume...

