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Testosterone Profiles After Brachytherapy for Localized Prostate Cancer
Hisanori Taniguchi1, Shigenari Kawakita1, Hidefumi Kinoshita1
1Department of Urology and Andrology, Kansai Medical University, Hirakata, Osaka, Japan.
Urology
|February 5, 2019
Summary
Serum total testosterone levels (STLs) in men with prostate cancer temporarily decreased after brachytherapy (BT) but recovered to baseline levels within 18 months, indicating a manageable impact on hormone levels.
Area of Science:
- Oncology
- Endocrinology
- Radiation Oncology
Background:
- Prostate cancer treatment often involves radiation, potentially affecting hormonal balance.
- Understanding the impact of brachytherapy on serum total testosterone levels (STLs) is crucial for patient management.
Purpose of the Study:
- To evaluate serum total testosterone levels (STLs) kinetics in patients following brachytherapy (BT) for localized prostate cancer.
- To identify predictors of testosterone decrease after BT.
Main Methods:
- 102 men with localized prostate cancer underwent permanent interstitial I125 brachytherapy without androgen deprivation therapy.
- Serum total testosterone levels (STLs) were monitored for 24-60 months post-treatment.
- Analysis included STL kinetics and predictors of testosterone decrease.
Main Results:
- Median baseline STL was 4.18 ng/mL.
- STLs significantly decreased to a median nadir of 89.4% of baseline at 6 months, recovering by 18 months.
- Lower baseline STLs predicted a greater decrease below 3.00 ng/mL (biochemical hypogonadism).
Conclusions:
- I125-based brachytherapy causes a temporary, not substantial, decrease in STLs for prostate cancer patients.
- Testosterone levels generally recover over time after brachytherapy.
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