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Congenital Insensitivity to Pain: A Misnomer
Asaf Weisman1, John Quintner2, Youssef Masharawi3
1Spinal Research Laboratory, Department of Physical Therapy, Stanley Steyer School of Health Professions, Sackler Faculty of Medicine, Tel Aviv University, Israel; Clalit Health Services, Department of Physical Therapy, Holon, Israel.
The Journal of Pain
|February 5, 2019
Summary
Congenital insensitivity to pain is an inaccurate term for rare genetic disorders. Researchers propose "congenital nociceptor deficiency" to better describe these conditions involving nociception.
Area of Science:
- Neuroscience
- Genetics
- Pain Research
Background:
- Congenital insensitivity to pain (CIP) is a rare genetic disorder.
- CIP is classified under hereditary sensory autonomic neuropathies.
- These conditions offer insights into nociception and pain perception.
Purpose of the Study:
- To review epistemological issues with the term "congenital insensitivity to pain."
- To demonstrate the inaccuracy of the current terminology.
- To propose a new, more accurate term: congenital nociceptor deficiency.
Main Methods:
- Literature review focusing on the epistemology of pain and nociception terminology.
- Analysis of the conflation of pain and nociception in existing literature.
- Proposal of alternative terminology based on current neurobiological understanding.
Main Results:
- The term "congenital insensitivity to pain" is epistemologically flawed.
- This term inaccurately conflates the concepts of pain and nociception.
- A new term, "congenital nociceptor deficiency," is suggested as more accurate.
Conclusions:
- The term "congenital insensitivity to pain" is misleading and scientifically inaccurate.
- "Congenital nociceptor deficiency" accurately reflects the underlying neurobiological condition.
- Adopting the new term will improve understanding and research in the field.
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