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Intercellular adhesion molecule-1 (ICAM-1) associates with 24-hour ambulatory blood pressure variability in type 2
Dana M Ciobanu1, Petru A Mircea2, Cornelia Bala1
1Iuliu Hatieganu University of Medicine and Pharmacy, Faculty of Medicine, Department of Diabetes and Nutrition, Cluj-Napoca, Romania.
Insights
Blood pressure variability is linked to higher levels of intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) in type 2 diabetes patients. This suggests variability may drive endothelial dysfunction through these adhesion molecules.
Area of Science:
- Cardiovascular Research
- Endocrinology
- Hypertension Research
Background:
- Endothelial dysfunction is prevalent in hypertension and type 2 diabetes.
- The role of blood pressure (BP) variability in influencing adhesion molecules like ICAM-1 and VCAM-1 is not fully understood.
- Understanding these associations may clarify mechanisms of endothelial dysfunction.
Purpose of the Study:
- To assess the association between circulating adhesion molecules (ICAM-1, VCAM-1) and ambulatory BP variability.
- To investigate these links in patients with type 2 diabetes and control subjects.
Main Methods:
- Included 55 type 2 diabetes patients with controlled BP, 55 with uncontrolled BP, and 28 controls.
- Measured serum ICAM-1 and VCAM-1 using enzyme-linked immunosorbent assay.
- Assessed BP variability via standard deviation of 24-hour ambulatory BP monitoring.
Main Results:
- Uncontrolled BP group showed significantly higher ICAM-1 and VCAM-1 levels.
- Higher ICAM-1 associated with increased daytime/24-hour diastolic BP variability and daytime systolic BP variability.
- VCAM-1 associated with daytime systolic BP variability.
Conclusions:
- Elevated 24-hour ambulatory BP variability may promote endothelial activation.
- Increased circulating adhesion molecules (ICAM-1, VCAM-1) are linked to BP variability in type 2 diabetes.
- Findings may enhance understanding of endothelial dysfunction mechanisms.
Background And Aim:
Endothelial dysfunction is a common feature in hypertension and type 2 diabetes. Whether blood pressure (BP) variability is influencing serum intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) remains to be clarified. We aimed to assess the association between the circulating adhesion molecules and ambulatory blood pressure variability in patients with type 2 diabetes and controls.
Patients And Methods:
The study included data from type 2 diabetes with controlled BP (n = 55), type 2 diabetes with uncontrolled BP (n = 55) and control subjects (n = 28). ICAM-1 and VCAM-1 were measured with specific enzyme-linked immunosorbent assay method. BP variability was assessed using standard deviation of mean systolic and diastolic BP evaluated during 24-hour ambulatory BP monitoring.
Results:
The uncontrolled BP type 2 diabetes group had significantly higher serum ICAM-1 and VCAM-1 levels compared to controlled BP type 2 diabetes and control groups. In linear regression analysis, after adjustment, higher ICAM-1 was consistently associated with higher daytime and 24-hour diastolic BP variability, and daytime systolic BP variability in the study population. VCAM-1 was associated only with daytime systolic BP variability.
Conclusions:
Our study evaluating the association of serum ICAM-1 and VCAM-1 with 24-hour ambulatory BP variability in patients with type 2 diabetes and controls might offer better understanding of the mechanisms generating endothelial dysfunction. Elevated 24-hour ambulatory BP variability might induce endothelial activation by increasing circulating adhesion molecules levels.
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