Role of immune complexes in cerebral malaria

To investigate the involvement of immune complexes in the pathogenesis of cerebral malaria, a comparative study between Plasmodium berghei infected Swiss albino mice and BALB/c mice was conducted. Rise in parasitemia was found to be same with differences in manifestation of disease and mortality, level of immune complexes and histopathology. Increased parasitized red cells with swelling of endothelial cells in the brain capillaries along with increased levels of circulating immune complexes were observed in the BALB/c mice.