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Adverse Hair Reactions to New Targeted Therapies for Cancer

J F Mir-Bonafé1, D Saceda-Corralo2, S Vañó-Galván2

  • 1Servicio de Dermatología, Hospital de la Santa Creu i Sant Pau, Barcelona, España.

Actas Dermo-Sifiliograficas
|February 6, 2019
PubMed

Insights

Targeted cancer therapies can cause unique hair changes. This review details adverse hair effects from these innovative immune-targeting drugs, aiding clinical understanding.

Area of Science:

  • Oncology
  • Dermatology
  • Pharmacology

Background:

  • Immune targeted therapies have revolutionized cancer treatment.
  • These therapies can cause novel dermatologic side effects, including hair changes.
  • Existing literature lacks a comprehensive overview of these adverse hair effects.

Purpose of the Study:

  • To systematically review and characterize adverse hair effects associated with targeted cancer therapies.
  • To consolidate information on hair-related side effects from various targeted drugs.
  • To provide a reference for clinicians managing these side effects.

Main Methods:

  • Exhaustive literature search was performed.
  • Studies reporting hair changes in patients receiving targeted therapies were included.
  • Data on hair growth, color, and shape alterations were extracted.

Main Results:

  • Targeted therapies can induce significant alterations in hair growth, including alopecia and hypertrichosis.
  • Changes in hair color (e.g., graying) and texture (e.g., wiry or curly hair) are commonly observed.
  • The specific hair effects vary depending on the targeted therapy used.

Conclusions:

  • Adverse hair effects are a notable consequence of immune targeted cancer therapies.
  • Understanding these effects is crucial for patient counseling and management.
  • Further research is needed to elucidate the mechanisms and develop interventions for these side effects.
Keywords:
AlopeciaAlteraciones capilaresCancer treatmentHairHair reactionsPeloTargeted therapiesTerapias dianaTratamiento oncológicoTrichologyTricología

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