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[Sports and Physical Exercise in Multiple Sclerosis].

Hirofumi Ochi1

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Exercise therapy shows promise for multiple sclerosis (MS) patients, offering potential anti-inflammatory and neuroprotective benefits beyond current disease-modifying drugs (DMDs). This approach may help manage neurological disability by addressing neurodegenerative processes in MS.

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Area of Science:

  • Neurology
  • Immunology
  • Rehabilitation Medicine

Background:

  • Multiple sclerosis (MS) is a central nervous system disease involving inflammation and neurodegeneration, leading to progressive disability.
  • Current disease-modifying drugs (DMDs) effectively manage inflammation but not neurodegeneration in MS.
  • Non-pharmacological interventions like exercise therapy are gaining attention for their potential benefits in MS management.

Purpose of the Study:

  • To review the general benefits of exercise therapy.
  • To provide an overview of the theoretical background for exercise therapy in MS.
  • To explore exercise therapy's potential disease-modifying effects in MS.

Main Methods:

  • Literature review of previous studies on exercise therapy.
  • Analysis of theoretical frameworks supporting exercise in MS.
  • Synthesis of current knowledge on exercise's impact on MS pathology.

Main Results:

  • Growing evidence suggests exercise therapy has anti-inflammatory effects in MS.
  • Exercise therapy may possess neuroprotective properties beneficial for MS patients.
  • The review consolidates understanding of exercise's role in managing MS.

Conclusions:

  • Exercise therapy presents a promising complementary approach for managing multiple sclerosis.
  • It may offer disease-modifying effects, particularly against neurodegenerative aspects of MS.
  • Further research into exercise's mechanisms and efficacy in MS is warranted.